Physicochemical Properties and Route of Systemic Delivery Control the In Vivo Dynamics and Breakdown of Radiolabeled Gold Nanostars.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202204293
Abstract: The in vivo dynamics of nanoparticles requires a mechanistic understanding of multiple factors. Here, for the first time, the surprising breakdown of functionalized gold nanostars (F-AuNSs) conjugated with antibodies and 64 Cu radiolabels in vivo… read more here.
Keywords: systemic delivery; vivo; vivo dynamics; route systemic ... See more keywords
Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.01.060
Abstract: Although bone tissues possess an intrinsic capacity for repair, there are cases where bone healing is either impaired or insufficient, such as fracture non-union, osteoporosis, osteomyelitis, and cancers. In these cases, treatments like surgical interventions… read more here.
Keywords: delivery; bone; bioactive agents; local systemic ... See more keywords
Systemic Delivery of Divalent Europium from Ligand Screening with Implications to Direct Imaging of Hypoxia.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10373
Abstract: Hypoxia is a hallmark of many diseases, including cancer, arthritis, heart and kidney diseases, and diabetes, and it is often associated with disease aggressiveness and poor prognosis. Consequently, there is a critical need for imaging… read more here.
Keywords: europium ligand; divalent europium; hypoxia; imaging hypoxia ... See more keywords
Optimization of amino acid-based poly(ester urea urethane) nanoparticles for the systemic delivery of gambogic acid for treating triple negative breast cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d3bm00128h
Abstract: Amino acid-based poly(ester urea urethane) (AA-PEUU) is developed from amino acid-based ester urea building blocks interconnected with urethane blocks functionalized with poly(ethylene glycol) (PEG). Each functional block consists of structural design features that could impact… read more here.
Keywords: acid based; ester urea; amino acid; systemic delivery ... See more keywords
Systemic delivery of MicroRNA mimics with polyethylenimine elevates pulmonary microRNA levels, but lacks pulmonary selectivity
Sign Up to like & getrecommendations! Published in 2018 at "Pulmonary Circulation"
DOI: 10.1177/2045893217750613
Abstract: Reversing pathologic alterations in vascular microRNA (miRNA) expression represents a potential therapeutic strategy for pulmonary hypertension. While polyethylenimine (PEI) has previously been shown to be an effective vehicle for vascular lung-directed delivery of plasmid DNA,… read more here.
Keywords: mimics polyethylenimine; microrna mimics; delivery; delivery microrna ... See more keywords
Characterization and Systemic Delivery of Dibenzoylmethane via the Intranasal Route
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01904-9
Abstract: Intranasal (IN) administration is known to be noninvasive with the potential to carry a drug or vaccine directly to the blood, bypassing first-pass metabolism in the liver and the harsh environment of the gastrointestinal system.… read more here.
Keywords: characterization systemic; delivery dibenzoylmethane; dbm; dibenzoylmethane via ... See more keywords
Duchenne muscular dystrophy disease severity impacts skeletal muscle progenitor cells systemic delivery
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1190524
Abstract: Duchenne muscular dystrophy (DMD) is caused by an out-of-frame mutation in the DMD gene that results in the absence of a functional dystrophin protein, leading to a devastating progressive lethal muscle-wasting disease. Muscle stem cell-based… read more here.
Keywords: cell; muscle; muscular dystrophy; systemic delivery ... See more keywords