IBRUTINIB INCREASES THE SYSTEMIC EXPOSURE OF RITUXIMAB: PHARMACOKINETIC RESULTS FROM THE HELIOS TRIAL
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2438_95
Abstract: decreased lymphoma‐specific mortality, adjusted HR 0.09 (0.01, 0.64). Further dose‐response analyses are planned. Conclusions: In this very large population‐based unselected lymphoma population, statins were not associated with worse outcomes and thus appear safe to use… read more here.
Keywords: pharmacokinetic results; exposure rituximab; ibrutinib increases; increases systemic ... See more keywords
Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Research"
DOI: 10.1007/s11095-019-2605-8
Abstract: IntroductionIn the HELIOS trial, bendamustine/rituximab (BR) plus ibrutinib (BR-I) improved disease outcomes versus BR plus placebo in previously treated chronic lymphocytic leukemia/small lymphocytic lymphoma. Here, we describe the pharmacokinetic (PK) observations, along with modeling to… read more here.
Keywords: rituximab; trial; exposure rituximab; systemic exposure ... See more keywords
Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice
Sign Up to like & getrecommendations! Published in 2017 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.06.002
Abstract: A number of clinical and experimental studies have revealed a strong association between periodontitis and accelerated cognitive decline in Alzheimer's disease (AD); however, the mechanism of the association is unknown. In the present study, we… read more here.
Keywords: catb; chronic systemic; mice; middle aged ... See more keywords
NQO1 and CYP450 reductase decrease the systemic exposure of rifampicin‐quinone and mediate its redox cycle in rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.09.040
Abstract: Graphical abstract Figure. No Caption available. HighlightsAn LC–MS method for the simultaneous determination of RIF and RIF‐Q was first developed and validated.A large amount of RIF‐Q was reduced to RIF and underwent redox cycle.CPR and… read more here.
Keywords: rif; redox cycle; systemic exposure;
Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00463
Abstract: To discover a novel series of potent inhibitors of enteropeptidase, a membrane-bound serine protease localized to the duodenal brush border, 4-guanidinobenzoate derivatives were evaluated with minimal systemic exposure. The 1c docking model enabled the installation… read more here.
Keywords: novel series; enteropeptidase inhibitors; systemic exposure; guanidinobenzoate derivatives ... See more keywords
Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c7ra13295f
Abstract: The promising benefits of salidroside (SAL) in alleviating high altitude sickness boost investigations on its pharmacokinetics and biological activity. However, the transportation and disposition process of SAL under hypoxic conditions has never been explored. The… read more here.
Keywords: sal; hypoxic rats; systemic exposure; cytosolic glucosidase ... See more keywords
Pathophysiological profile of awake and anesthetized pigs following systemic exposure to the highly lethal ricin toxin.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical toxicology"
DOI: 10.1080/15563650.2021.1933513
Abstract: Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor bean plant), is one of the most lethal toxins known. To date, no in-depth study of systemic exposure to ricin in a standardized… read more here.
Keywords: following systemic; ricin; exposure; exposure ricin ... See more keywords
Fragrances fuelling fibromyalgia? Patch tester's insights into a complex rheumatic disorder
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.18722
Abstract: Fibromyalgia (FM) affects millions of people worldwide, about 2% of adults, females twice as frequent as men.1 This rheumatic disorder is primarily characterized by chronic widespread pain of muscles, joints and connective tissues, along with… read more here.
Keywords: contact; systemic exposure; contact allergy; rheumatic disorder ... See more keywords
Systemic exposure and bioavailability of delgocitinib cream in adults with moderate to severe Chronic Hand Eczema
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.20777
Abstract: Chronic Hand Eczema (CHE) is a prevalent inflammatory skin condition characterized by pain, pruritus and significant impact on patients' quality of life. Delgocitinib cream, a pan‐Janus kinase inhibitor, has shown potential in targeting the key… read more here.
Keywords: systemic exposure; exposure bioavailability; delgocitinib cream; hand eczema ... See more keywords
SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia
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DOI: 10.3390/genes15010099
Abstract: This clinical study examined the influence of SLCO1B1 c.521T>C (rs4149056) on plasma atorvastatin concentrations in pediatric hypercholesterolemia. The participants (8–21 years), including heterozygous (c.521T/C, n = 13), homozygous (c.521C/C, n = 2) and controls (c.521T/T,… read more here.
Keywords: exposure pediatric; systemic exposure; variability ava; influence ... See more keywords
PBPK Modeling of Acetaminophen in Pediatric Populations: Incorporation of SULT Enzyme Ontogeny to Predict Age-Dependent Metabolism and Systemic Exposure
Sign Up to like & getrecommendations! Published in 2025 at "Life"
DOI: 10.3390/life15071099
Abstract: Sulfotransferase (SULT) enzymes contribute significantly to drug metabolism in pediatric patients. The purpose of this study was to develop a PBPK model for acetaminophen (APAP) in pediatric populations that accounts for the ontogeny of SULT… read more here.
Keywords: systemic exposure; pediatric populations; metabolism; pbpk modeling ... See more keywords