Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2076834
Abstract: ABSTRACT Introduction Cell transplantation is a promising curative therapeutic strategy whereby impaired organ function can be restored without the need for whole-organ transplantation. A key challenge in allotransplantation is the requirement for life-long systemic immunosuppression… read more here.
Keywords: systemic immunosuppression; transplantation; immunomodulatory; cell transplantation ... See more keywords
Characterization of systemic immunosuppression by IDH mutant glioma small extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-oncology"
DOI: 10.1093/neuonc/noab153
Abstract: BACKGROUND Gliomas are the most common primary brain tumors and are universally fatal. Mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) define a distinct glioma subtype associated with an immunosuppressive tumor microenvironment. Mechanisms underlying… read more here.
Keywords: glioma; immunosuppression idh; systemic immunosuppression; tex ... See more keywords