MITOCHONDRIAL DYSFUNCTION IN MACROPHGES LEADS TO SYSTEMIC INSULIN RESISTANCE, WHICH CAN BE IMPROVED BY GROWTH DIFFERENTIATION FACTOR 15
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DOI: 10.1097/01.hjh.0000539201.55483.18
Abstract: Objective: Although epidemiological studies have linked adipose inflammation with obesity, the underlying mechanisms are incomplete. It is widely accepted that the interaction between insulin target cells and pro-inflammatory cytokines from accumulated macrophages is a cause… read more here.
Keywords: insulin; systemic insulin; gdf15; insulin resistance ... See more keywords
Effect of systemic insulin treatment on diabetic wound healing
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DOI: 10.1111/wrr.12514
Abstract: This study investigates if different diabetic treatment regimens affect diabetic foot ulcer healing. From January 2013 to December 2014, 107 diabetic foot ulcers in 85 patients were followed until wound healing, amputation or development of… read more here.
Keywords: wound healing; systemic insulin; treatment; wound ... See more keywords
Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
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DOI: 10.1155/2017/9031079
Abstract: Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of… read more here.
Keywords: insulin; systemic insulin; sensitivity; normoglycemic women ... See more keywords
Insulin supplementation attenuates cancer-induced cardiomyopathy and slows tumor disease progression.
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DOI: 10.1172/jci.insight.93098
Abstract: Advanced cancer induces fundamental changes in metabolism and promotes cardiac atrophy and heart failure. We discovered systemic insulin deficiency in cachectic cancer patients. Similarly, mice with advanced B16F10 melanoma (B16F10-TM) or colon 26 carcinoma (C26-TM)… read more here.
Keywords: insulin; insulin supplementation; systemic insulin; cancer ... See more keywords