Articles with "systemic iron" as a keyword



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Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.

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Published in 2019 at "Cell metabolism"

DOI: 10.1016/j.cmet.2019.10.005

Abstract: Iron is a central micronutrient needed by all living organisms. Competition for iron in the intestinal tract is essential for the maintenance of indigenous microbial populations and for host health. How symbiotic relationships between hosts… read more here.

Keywords: iron homeostasis; microbial metabolite; metabolite signaling; systemic iron ... See more keywords
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20 years of Hepcidin: How far we have come.

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Published in 2021 at "Seminars in hematology"

DOI: 10.1053/j.seminhematol.2021.05.001

Abstract: Twenty years ago the discovery of hepcidin deeply changed our understanding of the regulation of systemic iron homeostasis. It is now clear that hepcidin orchestrates systemic iron levels by controlling the amount of iron exported… read more here.

Keywords: iron; years hepcidin; systemic iron; hepcidin far ... See more keywords
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Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin

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Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2212644120

Abstract: Significance Systemic iron metabolism is key for cellular and organismal function. However, the subcellular regulatory mechanisms of iron homeostasis remain poorly understood. This study highlights the pathophysiological significance of a principal cellular protein quality-control mechanism… read more here.

Keywords: iron; iron homeostasis; associated degradation; systemic iron ... See more keywords
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Systemic iron status and maternal pregnancy complications: A Mendelian randomization study

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Published in 2022 at "International journal of epidemiology"

DOI: 10.1093/ije/dyac037

Abstract: Iron deficiency is the most common nutritional deficiency worldwide, and is estimated to affect a quarter of the pregnant population.1 Low systemic iron levels have been associated with several maternal pregnancy complications, including infection and… read more here.

Keywords: maternal pregnancy; iron; iron status; pregnancy complications ... See more keywords
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Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing

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Published in 2020 at "Science"

DOI: 10.1126/science.aau6481

Abstract: Ironing out the details of mucosal healing Anemia is a frequent complication of disorders such as inflammatory bowel disease, occurring in part as a result of increased bleeding into the intestine. Bessman et al. show… read more here.

Keywords: derived hepcidin; mucosal healing; systemic iron; iron ... See more keywords
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Targeted autophagy disruption reveals the central role of macrophage iron metabolism in systemic iron homeostasis.

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Published in 2022 at "Blood"

DOI: 10.1182/blood.2021014493

Abstract: Iron homeostasis depends on both intracellular control through iron-responsive proteins and the systemic level of iron through hepcidin-ferroportin axis. Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and… read more here.

Keywords: role; iron; iron homeostasis; expression ... See more keywords
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Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention

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Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0204471

Abstract: The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney… read more here.

Keywords: iron; regulation iron; systemic iron; iron overload ... See more keywords
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Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders

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Published in 2022 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2021.794809

Abstract: Iron plays an important role in a wide range of metabolic pathways that are important for neuronal health. Excessive levels of iron, however, can promote toxicity and cell death. An example of an iron overload… read more here.

Keywords: iron overload; effects excess; iron; retina ... See more keywords
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Hfe Actions in Kupffer Cells Are Dispensable for Hepatic and Systemic Iron Metabolism

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Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24108948

Abstract: Mutations in the HFE/Hfe gene cause Hereditary Hemochromatosis (HH), a highly prevalent genetic disorder characterized by elevated iron deposition in multiple tissues. HFE acts in hepatocytes to control hepcidin expression, whereas HFE actions in myeloid… read more here.

Keywords: hfe actions; hepatic systemic; iron; kupffer cells ... See more keywords
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Appraising the Causal Association between Systemic Iron Status and Heart Failure Risk: A Mendelian Randomisation Study

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Published in 2022 at "Nutrients"

DOI: 10.3390/nu14163258

Abstract: Although observational studies have shown that abnormal systemic iron status is associated with an increased risk of heart failure (HF), it remains unclear whether this relationship represents true causality. We aimed to explore the causal… read more here.

Keywords: iron; iron status; risk; association ... See more keywords