Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.10.005
Abstract: Iron is a central micronutrient needed by all living organisms. Competition for iron in the intestinal tract is essential for the maintenance of indigenous microbial populations and for host health. How symbiotic relationships between hosts… read more here.
Keywords: iron homeostasis; microbial metabolite; metabolite signaling; systemic iron ... See more keywords
20 years of Hepcidin: How far we have come.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2021.05.001
Abstract: Twenty years ago the discovery of hepcidin deeply changed our understanding of the regulation of systemic iron homeostasis. It is now clear that hepcidin orchestrates systemic iron levels by controlling the amount of iron exported… read more here.
Keywords: iron; years hepcidin; systemic iron; hepcidin far ... See more keywords
Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212644120
Abstract: Significance Systemic iron metabolism is key for cellular and organismal function. However, the subcellular regulatory mechanisms of iron homeostasis remain poorly understood. This study highlights the pathophysiological significance of a principal cellular protein quality-control mechanism… read more here.
Keywords: iron; iron homeostasis; associated degradation; systemic iron ... See more keywords
Systemic iron status and maternal pregnancy complications: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "International journal of epidemiology"
DOI: 10.1093/ije/dyac037
Abstract: Iron deficiency is the most common nutritional deficiency worldwide, and is estimated to affect a quarter of the pregnant population.1 Low systemic iron levels have been associated with several maternal pregnancy complications, including infection and… read more here.
Keywords: maternal pregnancy; iron; iron status; pregnancy complications ... See more keywords
Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aau6481
Abstract: Ironing out the details of mucosal healing Anemia is a frequent complication of disorders such as inflammatory bowel disease, occurring in part as a result of increased bleeding into the intestine. Bessman et al. show… read more here.
Keywords: derived hepcidin; mucosal healing; systemic iron; iron ... See more keywords
Targeted autophagy disruption reveals the central role of macrophage iron metabolism in systemic iron homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014493
Abstract: Iron homeostasis depends on both intracellular control through iron-responsive proteins and the systemic level of iron through hepcidin-ferroportin axis. Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and… read more here.
Keywords: role; iron; iron homeostasis; expression ... See more keywords
The endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis.
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood.2025028454
Abstract: Liver sinusoidal endothelial cells (LSECs) are essential for maintaining liver function by actively sensing nutrients and producing angiocrine factors. LSECs also regulate systemic iron metabolism by secreting bone morphogenetic proteins (BMPs), key modulators of systemic… read more here.
Keywords: systemic iron; iron homeostasis; iron; foxo1 ... See more keywords
Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0204471
Abstract: The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney… read more here.
Keywords: iron; regulation iron; systemic iron; iron overload ... See more keywords
Pulsed electromagnetic field prevents lumbar bone loss in orchiectomy mice without altering systemic iron metabolism
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2025.1684162
Abstract: Background The therapeutic efficacies of pulsed electromagnetic fields (PEMFs) for postmenopausal osteoporosis are well established; however, their effects on male osteoporosis remain uncertain. Osteoporosis development is often associated with dysregulation of systemic iron metabolism. This… read more here.
Keywords: iron metabolism; mice; systemic iron; iron ... See more keywords
Effects of Excess Iron on the Retina: Insights From Clinical Cases and Animal Models of Iron Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.794809
Abstract: Iron plays an important role in a wide range of metabolic pathways that are important for neuronal health. Excessive levels of iron, however, can promote toxicity and cell death. An example of an iron overload… read more here.
Keywords: iron overload; effects excess; iron; retina ... See more keywords
Hfe Actions in Kupffer Cells Are Dispensable for Hepatic and Systemic Iron Metabolism
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108948
Abstract: Mutations in the HFE/Hfe gene cause Hereditary Hemochromatosis (HH), a highly prevalent genetic disorder characterized by elevated iron deposition in multiple tissues. HFE acts in hepatocytes to control hepcidin expression, whereas HFE actions in myeloid… read more here.
Keywords: hfe actions; hepatic systemic; iron; kupffer cells ... See more keywords