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Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.10.005
Abstract: Iron is a central micronutrient needed by all living organisms. Competition for iron in the intestinal tract is essential for the maintenance of indigenous microbial populations and for host health. How symbiotic relationships between hosts…
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Keywords:
iron homeostasis;
microbial metabolite;
metabolite signaling;
systemic iron ... See more keywords
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Published in 2021 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2021.05.001
Abstract: Twenty years ago the discovery of hepcidin deeply changed our understanding of the regulation of systemic iron homeostasis. It is now clear that hepcidin orchestrates systemic iron levels by controlling the amount of iron exported…
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Keywords:
iron;
years hepcidin;
systemic iron;
hepcidin far ... See more keywords
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Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212644120
Abstract: Significance Systemic iron metabolism is key for cellular and organismal function. However, the subcellular regulatory mechanisms of iron homeostasis remain poorly understood. This study highlights the pathophysiological significance of a principal cellular protein quality-control mechanism…
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Keywords:
iron;
iron homeostasis;
associated degradation;
systemic iron ... See more keywords
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Published in 2022 at "International journal of epidemiology"
DOI: 10.1093/ije/dyac037
Abstract: Iron deficiency is the most common nutritional deficiency worldwide, and is estimated to affect a quarter of the pregnant population.1 Low systemic iron levels have been associated with several maternal pregnancy complications, including infection and…
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Keywords:
maternal pregnancy;
iron;
iron status;
pregnancy complications ... See more keywords
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Published in 2020 at "Science"
DOI: 10.1126/science.aau6481
Abstract: Ironing out the details of mucosal healing Anemia is a frequent complication of disorders such as inflammatory bowel disease, occurring in part as a result of increased bleeding into the intestine. Bessman et al. show…
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Keywords:
derived hepcidin;
mucosal healing;
systemic iron;
iron ... See more keywords
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Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014493
Abstract: Iron homeostasis depends on both intracellular control through iron-responsive proteins and the systemic level of iron through hepcidin-ferroportin axis. Indeed, the hormone hepcidin downregulates the ferroportin iron exporter to control iron recycling from macrophages and…
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Keywords:
role;
iron;
iron homeostasis;
expression ... See more keywords
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Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0204471
Abstract: The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney…
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Keywords:
iron;
regulation iron;
systemic iron;
iron overload ... See more keywords
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Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.794809
Abstract: Iron plays an important role in a wide range of metabolic pathways that are important for neuronal health. Excessive levels of iron, however, can promote toxicity and cell death. An example of an iron overload…
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Keywords:
iron overload;
effects excess;
iron;
retina ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108948
Abstract: Mutations in the HFE/Hfe gene cause Hereditary Hemochromatosis (HH), a highly prevalent genetic disorder characterized by elevated iron deposition in multiple tissues. HFE acts in hepatocytes to control hepcidin expression, whereas HFE actions in myeloid…
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Keywords:
hfe actions;
hepatic systemic;
iron;
kupffer cells ... See more keywords
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Published in 2022 at "Nutrients"
DOI: 10.3390/nu14163258
Abstract: Although observational studies have shown that abnormal systemic iron status is associated with an increased risk of heart failure (HF), it remains unclear whether this relationship represents true causality. We aimed to explore the causal…
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Keywords:
iron;
iron status;
risk;
association ... See more keywords