mTORC1 restrains adipocyte lipolysis to prevent systemic hyperlipidemia
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.12.003
Abstract: Objective Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multiple roles… read more here.
Keywords: fed state; hyperlipidemia; mtorc1; lipolysis ... See more keywords
Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?
Sign Up to like & getrecommendations! Published in 2024 at "Bioengineering"
DOI: 10.3390/bioengineering11111135
Abstract: Introduction: Non-unions are fractures that do not heal properly, resulting in a false joint formation at the fracture site. This condition leads to major health issues and imposes a burden on national healthcare systems. The… read more here.
Keywords: fracture; lipid metabolism; systemic lipid; dysregulation ... See more keywords
TMEM41B, a novel ER phospholipid scramblase mediating systemic lipid metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022168
Abstract: The phospholipid molecules forming the phospholipid bilayer membrane have difficulties to complete spontaneous trans-bilayer shuttling due to the physicochemical properties and biological functions of the membrane bilayer [1]. However, this transbilayer phospholipid transport is essential… read more here.
Keywords: phospholipid scramblase; novel phospholipid; systemic lipid; mediating systemic ... See more keywords