Interventions for Cutaneous Disease in Systemic Lupus Erythematosus: Summary of a Cochrane Review.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2021.5485
Abstract: Clinical Question What is the efficacy of interventions for cutaneous disease in systemic lupus erythematosus (SLE) in randomized clinical trials (RCTs)? Bottom Line Available RCT evidence on the management of cutaneous disease in SLE is… read more here.
Keywords: disease; cutaneous disease; systemic lupus; interventions cutaneous ... See more keywords
Vascular-Targeted Therapy for Systemic Lupus Erythematosus-Associated Vasculitis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2023.0077
Abstract: This case report describes a woman in her 40s with a medical history of systemic lupus erythematosus with 1 year of tender papules, plaques, and progressive ulcers on her hands and feet. read more here.
Keywords: lupus erythematosus; targeted therapy; systemic lupus; vascular targeted ... See more keywords
Dnase1‐deficient mice spontaneously develop a systemic lupus erythematosus‐like disease
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847875
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease that has high morbidity and can result in multi‐organ damage. SLE is characterized by dysregulated activation of T‐ and B‐lymphocytes and the production of autoantibodies directed against… read more here.
Keywords: dnase1 deficient; systemic lupus; lupus erythematosus; disease ... See more keywords
Systemic lupus erythematosus patients contain B‐cell receptor repertoires sensitive to immunosuppressive drugs
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149596
Abstract: Immune repertoire (IR) during treatment may be a surrogate biomarker for disease response. Changes of the IR in systemic lupus erythematosus patients in response to immunosuppressive drugs were identified in ten SLE patients. Patients provided… read more here.
Keywords: sensitive group; erythematosus patients; immunosuppressive drugs; group ... See more keywords
Persistently active interferon-γ pathway and expansion of T-bet+ B cells in a subset of patients with childhood-onset systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250319
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease causing significant morbidity and mortality, despite important improvements in its management in the last decades. The objective of this work is to investigate the role of IFN-γ… read more here.
Keywords: lupus erythematosus; ifn; systemic lupus; bet ... See more keywords
Interferon-α regulates abnormally increased expression of RSAD2 in Th17 and Tfh cells in systemic lupus erythematosus patients.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350420
Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that often involves abnormal activation of regulatory interferon genes and regulation of B cells by CD4+ T cells. RSAD2 is a viral suppressor protein regulated by… read more here.
Keywords: tfh cells; th17; expression; systemic lupus ... See more keywords
Ophiopogonin D attenuates the progression of murine systemic lupus erythematosus by reducing B cell numbers.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23361
Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune abnormalities leading to multi-organ damage. The activation of autoreactive B cell differentiation will lead to the production of pathogenic autoantibodies, contributing to the… read more here.
Keywords: cell; reducing cell; cell numbers; systemic lupus ... See more keywords
Serum amyloid A‐to‐albumin ratio as a potential biomarker to predict the activity, severity, and poor prognosis of systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24282
Abstract: To evaluate the predictive value of serum amyloid A‐to‐albumin ratio (SAR) for active systemic lupus erythematosus (SLE), severe active SLE, and poor prognosis of SLE. read more here.
Keywords: lupus erythematosus; serum amyloid; poor prognosis; systemic lupus ... See more keywords
Association between genetic variants of microRNA‐21 and microRNA‐155 and systemic lupus erythematosus: A case‐control study from a Chinese population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24518
Abstract: Systemic lupus erythematosus (SLE) is a common autoimmune disease, and its pathogenesis remains unclear. The alteration of genetic materials is believed to play a role in SLE development. This study evaluated the association between the… read more here.
Keywords: genetic variants; systemic lupus; lupus erythematosus; variants microrna ... See more keywords
Relationship Between Anifrolumab Pharmacokinetics, Pharmacodynamics, and Efficacy in Patients With Moderate to Severe Systemic Lupus Erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.2054
Abstract: This study aimed to elucidate the pharmacokinetic/pharmacodynamic and pharmacodynamic/efficacy relationships of anifrolumab, a type I interferon receptor antibody, in patients with moderate to severe systemic lupus erythematosus. Data were pooled from the randomized, 52‐week, placebo‐controlled… read more here.
Keywords: neutralization; efficacy; systemic lupus; lupus erythematosus ... See more keywords
Diffuse alveolar hemorrhage in a pediatric patient with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26308
Abstract: A 15‐year‐old female patient was initially transferred due to symptomatic anemia following months of menorrhagia, fatigue, dyspnea, and weight loss. Early during her hospital course, pulmonary complications occurred with the development of respiratory failure secondary… read more here.
Keywords: level; patient; systemic lupus; lupus erythematosus ... See more keywords