Dysregulation of Adenosinergic Signaling in Systemic and Organ-Specific Autoimmunity
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DOI: 10.3390/ijms20030528
Abstract: Exact causes for autoimmune diseases remain unclear and no cures are available. Breakdown of immunotolerance could set the stage for unfettered immune responses that target self-antigens. Impaired regulatory immune mechanisms could have permissive roles in… read more here.
Keywords: specific autoimmunity; dysregulation adenosinergic; organ specific; systemic organ ... See more keywords
Monte Carlo Models for Sub-Chronic Repeated-Dose Toxicity: Systemic and Organ-Specific Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126615
Abstract: The risk-characterization of chemicals requires the determination of repeated-dose toxicity (RDT). This depends on two main outcomes: the no-observed-adverse-effect level (NOAEL) and the lowest-observed-adverse-effect level (LOAEL). These endpoints are fundamental requirements in several regulatory frameworks,… read more here.
Keywords: systemic organ; organ specific; sub chronic; toxicity ... See more keywords