A review on applications of abatacept in systemic rheumatic diseases.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107612
Abstract: Abatacept is a CTLA-4Ig fusion protein that selectively modulates the CD80/CD86:CD28 costimulatory pathway required for full T-cell activation. The FDA has approved it to be used to treat adult rheumatoid arthritis, juvenile idiopathic arthritis, and… read more here.
Keywords: review applications; abatacept systemic; rheumatic diseases; applications abatacept ... See more keywords
Low Peripheral B-Cell Counts in Patients With Systemic Rheumatic Diseases Due to Treatment With Belimumab and/or Rituximab Are Associated With Low Antibody Responses to Primary COVID-19 Vaccination
Sign Up to like & getrecommendations! Published in 2022 at "HSS Journal"
DOI: 10.1177/15563316221142846
Abstract: Background: Immunosuppressive agents inhibit COVID-19 vaccine antibody (Ab) responses in patients with systemic rheumatic diseases. Rituximab may fully block Ab responses when B cells become undetected. The effect of detected but low number of B… read more here.
Keywords: cell; rheumatic diseases; belimumab rituximab; cell counts ... See more keywords
Malignancies in systemic rheumatic diseases: A mini review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1095526
Abstract: There is an increased risk of malignancies in patients with many systemic rheumatic diseases, which negatively impact on their quality of life. The risk and types of malignancies can differ by the type of rheumatic… read more here.
Keywords: rheumatic diseases; mini review; risk; malignancies systemic ... See more keywords
Lung Infections in Systemic Rheumatic Disease: Focus on Opportunistic Infections
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18020293
Abstract: Systemic rheumatic diseases have significant morbidity and mortality, due in large part to concurrent infections. The lung has been reported among the most frequent sites of infection in patients with rheumatic disease, who are susceptible… read more here.
Keywords: infections lung; rheumatic diseases; rheumatic disease; disease ... See more keywords
Blocking IL-17: A Promising Strategy in the Treatment of Systemic Rheumatic Diseases
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21197100
Abstract: Systemic rheumatic diseases are a heterogeneous group of autoimmune disorders that affect the connective tissue, characterized by the involvement of multiple organs, leading to disability, organ failure and premature mortality. Despite the advances in recent… read more here.
Keywords: strategy treatment; promising strategy; rheumatic diseases; systemic rheumatic ... See more keywords
Autoimmune liver diseases in systemic rheumatic diseases
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i23.2527
Abstract: Systemic rheumatic diseases (SRDs) are chronic, inflammatory, autoimmune disorders with the presence of autoantibodies that may affect any organ or system. Liver dysfunction in SRDs can be associated with prescribed drugs, viral hepatitis, alternative hepatic… read more here.
Keywords: rheumatic diseases; overlap diseases; liver diseases; autoimmune liver ... See more keywords