Landscape of systemic therapy for ovarian cancer in 2019: Primary therapy
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DOI: 10.1002/cncr.32475
Abstract: According to the statement from the 5th Ovarian Cancer Consensus Conference in 2015, the primary systemic chemotherapy for advanced ovarian cancer is a combination of paclitaxel plus carboplatin administered every 3 weeks (PCq3w). Optional alternatives… read more here.
Keywords: therapy; systemic therapy; therapy ovarian; landscape systemic ... See more keywords
A comparison of local therapy alone with local plus systemic therapy for stage I pT1aN0M0 HER2+ breast cancer: A National Cancer Database analysis
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DOI: 10.1002/cncr.34200
Abstract: Small invasive breast cancers (BCs) with tumor sizes ≤5 mm (T1a) are associated with an excellent prognosis without systemic therapy. Although HER2 overexpression (HER2+) is associated with a higher risk of recurrence and poorer clinical… read more here.
Keywords: pt1an0m0; breast; her2; therapy ... See more keywords
Nodal positivity and systemic therapy among patients with clinical T1–T2N0 human epidermal growth factor receptor‐positive breast cancer: Results from two international cohorts
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DOI: 10.1002/cncr.34750
Abstract: The optimal treatment strategy for patients with small human epidermal growth factor receptor 2 (HER2)‐positive tumors is based on nodal status. The authors’ objective was to evaluate pathologic nodal disease (pathologic lymph node‐positive [pN‐positive] and… read more here.
Keywords: epidermal growth; factor receptor; growth factor; human epidermal ... See more keywords
SYSTEMIC THERAPY AFTER RADIATION THERAPY IN STAGE I‐II FOLLICULAR LYMPHOMA: FINAL RESULTS OF AN INTERNATIONAL RANDOMIZED TRIAL TROG 99.03
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DOI: 10.1002/hon.35_2630
Abstract: chemotherapy. With a median follow up of 73.8 months the local progression free survival at 3 years was 90.9% after 24Gy and 74.6% after 4Gy; the corresponding rates at 5 years are 89.9% after 24Gy… read more here.
Keywords: radiation therapy; systemic therapy; local progression; therapy radiation ... See more keywords
A propensity score‐matched analysis of oncological outcome after systemic therapy for stage IV colorectal cancer: Impact of synchronous ovarian metastases
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DOI: 10.1002/ijc.34325
Abstract: The reported incidence of synchronous and metachronous ovarian metastases (OM) from colorectal cancer (CRC) is ~3.4%. OM from CRC are often considered sanctuary sites due to their lower sensitivity to systemic treatment. It has thus… read more here.
Keywords: propensity score; therapy; ovarian metastases; cancer ... See more keywords
Current Progress in the Systemic Therapy for Biliary Tract Cancers.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hepato-biliary-pancreatic sciences"
DOI: 10.1002/jhbp.939
Abstract: BACKGROUND Biliary tract cancers (BTCs) are heterogeneous cancers that include cancers of the bile duct and gallbladder. Although they are relatively uncommon, most patients with BTC are diagnosed at advanced-stage disease with high mortality rates.… read more here.
Keywords: biliary tract; current progress; systemic therapy; tract cancers ... See more keywords
Quantitative Apparent Diffusion Coefficients From Peritumoral Regions as Early Predictors of Response to Neoadjuvant Systemic Therapy in Triple‐Negative Breast Cancer
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DOI: 10.1002/jmri.28219
Abstract: Pathologic complete response (pCR) to neoadjuvant systemic therapy (NAST) in triple‐negative breast cancer (TNBC) is a strong predictor of patient survival. Edema in the peritumoral region (PTR) has been reported to be a negative prognostic… read more here.
Keywords: triple negative; breast cancer; neoadjuvant systemic; response ... See more keywords
Primary systemic therapy in resectable pancreatic ductal adenocarcinoma using mFOLFIRINOX: A pilot study
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DOI: 10.1002/jso.24872
Abstract: Surgery followed by gemcitabine and/or a fluoropyrimidine is standard therapy for resectable PDAC. mFOLFIRINOX (oxaliplatin 85 mg/m2, irinotecan 180 mg/m2, leucovorin 400 mg/m2 Day 1, 5‐FU 2400 mg/m2 × 48 h IV, peg‐filgrastim 6 mg SQ day 3, every 14 days) has substantial… read more here.
Keywords: systemic therapy; resectable pancreatic; primary systemic; mfolfirinox ... See more keywords
Systemic therapy in retroperitoneal sarcoma management
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DOI: 10.1002/jso.24933
Abstract: There is paucity of randomized controlled data on the role of systemic therapy in retroperitoneal sarcomas. The type of systemic therapy used is guided by the histological subtype. The majority of retroperitoneal sarcomas comprising liposarcomas… read more here.
Keywords: retroperitoneal; systemic therapy; retroperitoneal sarcomas; therapy retroperitoneal ... See more keywords
Defining the role of systemic therapy in resectable pancreatic acinar cell carcinoma
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DOI: 10.1002/jso.26785
Abstract: Following resection of pancreatic acinar cell carcinoma (PACC) distant recurrence remains high. We utilized the national cancer database (NCDB) to evaluate the role of systemic therapy in early‐stage resected PACC. read more here.
Keywords: cell carcinoma; role systemic; pancreatic acinar; acinar cell ... See more keywords
Systemic therapy for gastric cancer: Perioperative strategies and beyond
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DOI: 10.1002/jso.26834
Abstract: Each year, gastric cancer claims the lives of hundreds of thousands of patients worldwide. Despite surgical resection, the risk of residual disease, micrometastatic disease, and disease recurrence remain elevated. Herein, we review systemic therapy strategies… read more here.
Keywords: cancer perioperative; therapy gastric; gastric cancer; cancer ... See more keywords