Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging
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DOI: 10.1002/pmic.201800420
Abstract: All organisms age, but the extent to which all organisms age the same way remains a fundamental unanswered question in biology. Across species, it is now clear that at least some aspects of aging are… read more here.
Keywords: yeast illuminate; aging systems; biology; systems biology ... See more keywords
Synthesizing Systems Biology Knowledge from Omics Using Genome‐Scale Models
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DOI: 10.1002/pmic.201900282
Abstract: Omic technologies have enabled the complete readout of the molecular state of a cell at different biological scales. In principle, the combination of multiple omic data types can provide an integrated view of the entire… read more here.
Keywords: genome scale; scale models; omic data; biology ... See more keywords
Future Challenges in Plant Systems Biology.
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DOI: 10.1007/978-1-0716-1816-5_16
Abstract: Plant systems biology is currently facing several important challenges, whose nature depend on the considered frame of reference and associated scale. This review covers some of the issues associated respectively with the molecular, tissue, and… read more here.
Keywords: plant; biology future; plant systems; biology ... See more keywords
Bioinformatics Analysis of Protein Phosphorylation in Plant Systems Biology Using P3DB.
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DOI: 10.1007/978-1-4939-6783-4_6
Abstract: Protein phosphorylation is one of the most pervasive protein post-translational modification events in plant cells. It is involved in many plant biological processes, such as plant growth, organ development, and plant immunology, by regulating or… read more here.
Keywords: plant; protein phosphorylation; biology; systems biology ... See more keywords
Conceptual Challenges in the Theoretical Foundations of Systems Biology.
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DOI: 10.1007/978-1-4939-7456-6_1
Abstract: In the last decade, Systems Biology has emerged as a conceptual and explanatory alternative to reductionist-based approaches in molecular biology. However, the foundations of this new discipline need to be fleshed out more carefully. In… read more here.
Keywords: biology conceptual; ontology; challenges theoretical; conceptual challenges ... See more keywords
Inverse Problems in Systems Biology: A Critical Review.
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DOI: 10.1007/978-1-4939-7456-6_6
Abstract: Systems Biology may be assimilated to a symbiotic cyclic interplaying between the forward and inverse problems. Computational models need to be continuously refined through experiments and in turn they help us to make limited experimental… read more here.
Keywords: biology; inverse problems; problems systems; critical review ... See more keywords
Parameters Estimation in Phase-Space Landscape Reconstruction of Cell Fate: A Systems Biology Approach.
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DOI: 10.1007/978-1-4939-7456-6_8
Abstract: The thermodynamical formalism of irreversible processes offers a theoretical framework appropriate to explain the complexity observed at the macroscopic level of dynamic systems. In this context, together with the theory of complex systems and systems… read more here.
Keywords: space landscape; estimation phase; parameters estimation; phase space ... See more keywords
Systems Biology Methods for Alzheimer's Disease Research Toward Molecular Signatures, Subtypes, and Stages and Precision Medicine: Application in Cohort Studies and Trials.
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DOI: 10.1007/978-1-4939-7704-8_3
Abstract: Alzheimer's disease (AD) is a complex multifactorial disease, involving a combination of genomic, interactome, and environmental factors, with essential participation of (a) intrinsic genomic susceptibility and (b) a constant dynamic interplay between impaired pathways and… read more here.
Keywords: medicine; biology methods; disease; biology ... See more keywords
Transkingdom Networks: A Systems Biology Approach to Identify Causal Members of Host-Microbiota Interactions.
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DOI: 10.1007/978-1-4939-8728-3_15
Abstract: Improvements in sequencing technologies and reduced experimental costs have resulted in a vast number of studies generating high-throughput data. Although the number of methods to analyze these "omics" data has also increased, computational complexity and… read more here.
Keywords: biology approach; causal; biology; systems biology ... See more keywords
Detecting Common Pathways and Key Molecules of Neurodegenerative Diseases from the Topology of Molecular Networks.
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DOI: 10.1007/978-3-030-32622-7_38
Abstract: MotivationNeurodegenerative diseases (NDs), including amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease, occur as a result of neurodegenerative processes. Thus, it has been increasingly appreciated that many neurodegenerative conditions overlap at multiple levels.… read more here.
Keywords: detecting common; neurodegenerative diseases; disease; topology ... See more keywords
Introduction: Advances in Plant Omics and Systems Biology.
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DOI: 10.1007/978-3-030-80352-0_1
Abstract: How the complexity of biological systems can be understood is currently limited by the amount of biological information we have available to be incorporate in the vastitude of possibilities that could represent how a biological… read more here.
Keywords: introduction advances; biology introduction; advances plant; biology ... See more keywords