Resources for Systems Genetics.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6427-7_1
Abstract: A key characteristic of systems genetics is its reliance on populations that vary to a greater or lesser degree in genetic complexity-from highly admixed populations such as the Collaborative Cross and Diversity Outcross to relatively… read more here.
Keywords: systems genetics; genetics; biology; resources systems ... See more keywords
Integrative Functional Genomics for Systems Genetics in GeneWeaver.org.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6427-7_6
Abstract: The abundance of existing functional genomics studies permits an integrative approach to interpreting and resolving the results of diverse systems genetics studies. However, a major challenge lies in assembling and harmonizing heterogeneous data sets across… read more here.
Keywords: geneweaver org; integrative functional; genetics; functional genomics ... See more keywords
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23649-0
Abstract: Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here,… read more here.
Keywords: diversity outbred; genetics; bmd; outbred mice ... See more keywords
Xylem systems genetics analysis reveals a key regulator of lignin biosynthesis in Populus deltoides.
Sign Up to like & getrecommendations! Published in 2020 at "Genome research"
DOI: 10.1101/gr.261438.120
Abstract: Despite the growing resources and tools for high-throughput characterization and analysis of genomic information, the discovery of the genetic elements that regulate complex traits remains a challenge. Systems genetics is an emerging field that aims… read more here.
Keywords: lignin biosynthesis; genetics; analysis; populus deltoides ... See more keywords
Systems genetics approach reveals cross-talk between bile acids and intestinal microbes
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008307
Abstract: The emerging role of the gut microbiome in human pathophysiology has led to a paradigm shift in our view of complex traits, moving us from a “genetics–environment” interaction model to one that encompasses “genetics–microbes–environment.” Within… read more here.
Keywords: bile acids; qtl; genetics; qtl microbe ... See more keywords
Exploring the pathogenesis of canine epilepsy using a systems genetics method and implications for anti-epilepsy drug discovery
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23719
Abstract: Epilepsy is a common neurological disorder in domestic dogs. However, its complex mechanism involves multiple genetic and environmental factors that make it challenging to identify the real pathogenic factors contributing to epilepsy, particularly for idiopathic… read more here.
Keywords: genetics method; genetics; drug; systems genetics ... See more keywords
Inferring bona fide Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a Systems Genetics Approach
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13112078
Abstract: Systems genetics is key for integrating a large number of variants associated with diseases. Vitamin K (VK) is one of the scarcely studied disease conditions. In this work, we ascertained the differentially expressed genes (DEGs)… read more here.
Keywords: variants associated; expressed genes; differentially expressed; systems genetics ... See more keywords