A Systems-Level Approach to Improving Medication Adherence in Hypertensive Latinos: a Randomized Control Trial
Sign Up to like & getrecommendations! Published in 2019 at "Journal of General Internal Medicine"
DOI: 10.1007/s11606-019-05419-3
Abstract: Background Despite numerous interventions targeting medication adherence in patients with uncontrolled hypertension, practice-based trials in Latino patients are scant. Objective To evaluate the effect of a systems-level adherence intervention, delivered by medical assistants (MAs), versus… read more here.
Keywords: intervention; trial; medication adherence; systems level ... See more keywords
Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.04.025
Abstract: Summary HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets have been associated with Vif, Vpu, and… read more here.
Keywords: promiscuous targeting; proteins vpr; targeting cellular; cellular proteins ... See more keywords
Tackling Antibiotic Resistance with Systems-Level Perspective.
Sign Up to like & getrecommendations! Published in 2017 at "Cell systems"
DOI: 10.1016/j.cels.2017.12.002
Abstract: Quantitative dissection of regulatory motifs could lead to new ways to fight antibiotic resistance. read more here.
Keywords: resistance systems; level perspective; resistance; antibiotic resistance ... See more keywords
A systems-level approach for investigating organophosphorus pesticide toxicity.
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2017.10.066
Abstract: The full understanding of the single and joint toxicity of a variety of organophosphorus (OP) pesticides is still unavailable, because of the extreme complex mechanism of action. This study established a systems-level approach based on… read more here.
Keywords: pesticide toxicity; level approach; toxicity; approach investigating ... See more keywords
Evaluation of a systems-level technical assistance program to support youth with complex behavioral health needs.
Sign Up to like & getrecommendations! Published in 2022 at "Evaluation and program planning"
DOI: 10.1016/j.evalprogplan.2022.102059
Abstract: The National Technical Assistance Network for Children's Behavioral Health (TA Network) supports the development and implementation of Systems of Care (SOC) for youth with serious emotional disorders and their families in states, tribes, territories, and… read more here.
Keywords: support; behavioral health; systems level; technical assistance ... See more keywords
Systems-Level Analysis of Phosphorus Flows in the Dairy Supply Chain
Sign Up to like & getrecommendations! Published in 2019 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.9b03129
Abstract: The dairy sector plays a vital role in the food supply chain, but it is also highly resource-intensive, consuming vast amounts of water, energy, and nutrients. Nutrients such as phosphorus (P) are key economic drivers… read more here.
Keywords: dairy; dairy sector; systems level; supply chain ... See more keywords
An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09726-4
Abstract: Ochratoxin A (OTA) is one of the most widespread mycotoxin contaminants of agricultural crops. Despite being associated with a range of adverse health effects, a comprehensive systems-level mechanistic understanding of the toxicity of OTA remains… read more here.
Keywords: metabolic profiling; systems level; toxicity; ochratoxin ... See more keywords
How to interpret and integrate multi-omics data at systems level
Sign Up to like & getrecommendations! Published in 2020 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2020.1721321
Abstract: ABSTRACT Current parallel sequencing technologies generate biological sequence data explosively and enable omics studies that analyze collective biological features. The more omics data that is accumulated, the more they show the regulatory complexity of biological… read more here.
Keywords: integrate multi; multi omics; interpret integrate; omics data ... See more keywords
A systems-level analysis of drug–target–disease associations for drug repositioning
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in Functional Genomics"
DOI: 10.1093/bfgp/elx015
Abstract: Drug repositioning is the process of finding new therapeutic uses for existing, approved drugs-a process thathas value when considering the exorbitant costs of novel drug development. Several computational strategies exist as a way to predict… read more here.
Keywords: drug targets; level analysis; drug repositioning; drug ... See more keywords
Systems-level analysis of the plasticity of the maize metabolic network reveals novel hypotheses in the nitrogen-use efficiency of maize roots
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erab522
Abstract: This article comments on: Chowdhury NB, Schroeder WL, Sarkar D, Amiour N, Quilleré I, Hirel B, Maranas CD, Saha R. 2022. Dissecting the metabolic reprogramming of maize root under nitrogen-deficient stress conditions. Journal of Experimental… read more here.
Keywords: level analysis; plasticity maize; systems level; analysis plasticity ... See more keywords
Phenotype‐specific signatures of systems‐level gut microbiome associated with childhood airway allergies
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.13905
Abstract: Perturbation of gut symbiosis has been linked to childhood allergic diseases. However, the underlying host–microbe interaction connected with specific phenotypes is poorly understood. read more here.
Keywords: level gut; phenotype specific; signatures systems; childhood ... See more keywords