LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "systems level" as a keyword



A Systems-Level Approach to Improving Medication Adherence in Hypertensive Latinos: a Randomized Control Trial

Sign Up to like & get
recommendations! Published in 2019 at "Journal of General Internal Medicine"

DOI: 10.1007/s11606-019-05419-3

Abstract: Background Despite numerous interventions targeting medication adherence in patients with uncontrolled hypertension, practice-based trials in Latino patients are scant. Objective To evaluate the effect of a systems-level adherence intervention, delivered by medical assistants (MAs), versus… read more here.

Keywords: intervention; trial; medication adherence; systems level ... See more keywords
Photo by nci from unsplash

Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection

Sign Up to like & get
recommendations! Published in 2019 at "Cell Reports"

DOI: 10.1016/j.celrep.2019.04.025

Abstract: Summary HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets have been associated with Vif, Vpu, and… read more here.

Keywords: promiscuous targeting; proteins vpr; targeting cellular; cellular proteins ... See more keywords
Photo by nci from unsplash

Tackling Antibiotic Resistance with Systems-Level Perspective.

Sign Up to like & get
recommendations! Published in 2017 at "Cell systems"

DOI: 10.1016/j.cels.2017.12.002

Abstract: Quantitative dissection of regulatory motifs could lead to new ways to fight antibiotic resistance. read more here.

Keywords: resistance systems; level perspective; resistance; antibiotic resistance ... See more keywords

A systems-level approach for investigating organophosphorus pesticide toxicity.

Sign Up to like & get
recommendations! Published in 2018 at "Ecotoxicology and environmental safety"

DOI: 10.1016/j.ecoenv.2017.10.066

Abstract: The full understanding of the single and joint toxicity of a variety of organophosphorus (OP) pesticides is still unavailable, because of the extreme complex mechanism of action. This study established a systems-level approach based on… read more here.

Keywords: pesticide toxicity; level approach; toxicity; approach investigating ... See more keywords

Evaluation of a systems-level technical assistance program to support youth with complex behavioral health needs.

Sign Up to like & get
recommendations! Published in 2022 at "Evaluation and program planning"

DOI: 10.1016/j.evalprogplan.2022.102059

Abstract: The National Technical Assistance Network for Children's Behavioral Health (TA Network) supports the development and implementation of Systems of Care (SOC) for youth with serious emotional disorders and their families in states, tribes, territories, and… read more here.

Keywords: support; behavioral health; systems level; technical assistance ... See more keywords

Systems-Level Analysis of Phosphorus Flows in the Dairy Supply Chain

Sign Up to like & get
recommendations! Published in 2019 at "ACS Sustainable Chemistry & Engineering"

DOI: 10.1021/acssuschemeng.9b03129

Abstract: The dairy sector plays a vital role in the food supply chain, but it is also highly resource-intensive, consuming vast amounts of water, energy, and nutrients. Nutrients such as phosphorus (P) are key economic drivers… read more here.

Keywords: dairy; dairy sector; systems level; supply chain ... See more keywords

Systems-Level Modeling for CRISPR-Based Metabolic Engineering.

Sign Up to like & get
recommendations! Published in 2024 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.4c00053

Abstract: The CRISPR-Cas system has enabled the development of sophisticated, multigene metabolic engineering programs through the use of guide RNA-directed activation or repression of target genes. To optimize biosynthetic pathways in microbial systems, we need improved… read more here.

Keywords: systems level; engineering; guide rna; metabolic engineering ... See more keywords
Photo from wikipedia

An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling

Sign Up to like & get
recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-09726-4

Abstract: Ochratoxin A (OTA) is one of the most widespread mycotoxin contaminants of agricultural crops. Despite being associated with a range of adverse health effects, a comprehensive systems-level mechanistic understanding of the toxicity of OTA remains… read more here.

Keywords: metabolic profiling; systems level; toxicity; ochratoxin ... See more keywords

Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production

Sign Up to like & get
recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2307904121

Abstract: Significance Mitochondrial respiration generates both energy (ATP) and reactive oxygen species (ROS). Insufficient energy and increased ROS from respiratory chain dysfunction may be central to the pathophysiology of neurodegenerative diseases and aging. We established a… read more here.

Keywords: systems level; energy; oxygen species; respiratory chain ... See more keywords
Photo from wikipedia

How to interpret and integrate multi-omics data at systems level

Sign Up to like & get
recommendations! Published in 2020 at "Animal Cells and Systems"

DOI: 10.1080/19768354.2020.1721321

Abstract: ABSTRACT Current parallel sequencing technologies generate biological sequence data explosively and enable omics studies that analyze collective biological features. The more omics data that is accumulated, the more they show the regulatory complexity of biological… read more here.

Keywords: integrate multi; multi omics; interpret integrate; omics data ... See more keywords

A systems-level analysis of drug–target–disease associations for drug repositioning

Sign Up to like & get
recommendations! Published in 2018 at "Briefings in Functional Genomics"

DOI: 10.1093/bfgp/elx015

Abstract: Drug repositioning is the process of finding new therapeutic uses for existing, approved drugs-a process thathas value when considering the exorbitant costs of novel drug development. Several computational strategies exist as a way to predict… read more here.

Keywords: drug targets; level analysis; drug repositioning; drug ... See more keywords