Boolean network modeling in systems pharmacology
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-017-9567-4
Abstract: Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover how drugs modulate the dynamics of biological components in molecular and cellular networks and the impact of those perturbations on human pathophysiology. The… read more here.
Keywords: network modeling; network; network models; boolean network ... See more keywords
A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability
Sign Up to like & getrecommendations! Published in 2022 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-021-00982-5
Abstract: There is an inherent tension in Quantitative Systems Pharmacology (QSP) between the need to incorporate mathematical descriptions of complex physiology and drug targets with the necessity of developing robust, predictive and well-constrained models. In addition… read more here.
Keywords: identifiability; parameter identifiability; pharmacology; systems pharmacology ... See more keywords
A systems pharmacology approach to investigate the mechanism of Oryeong-san formula for the treatment of hypertension.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112129
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Oryeong-san (ORS) is a traditional formula that has long been used for the treatment of dysfunctions of body fluids and electrolyte homeostasis in Korea, China and Japan. Recent reports have shown that ORS… read more here.
Keywords: pharmacology approach; systems pharmacology; pharmacology; hypertension ... See more keywords
Deciphering the multicomponent synergy mechanism from a systems pharmacology perspective: Application to Gualou Xiebai Decoction for coronary heart disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2018.02.030
Abstract: Abstract Coronary heart disease (CHD) is often accompanied with diabetes mellitus, which leads the limited effect of monotherapy. Drug combinations are deemed to a promising approach for treating CHD, and traditional Chinese medicine (TCM) formulas… read more here.
Keywords: heart disease; systems pharmacology; xiebai decoction; pharmacology ... See more keywords
Systems pharmacology dissection of action mechanisms of Dipsaci Radix for osteoporosis.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116820
Abstract: AIMS Osteoporosis (OP) is a systemic metabolic bone disease characterized by bone mass decrease and microstructural degradation, which may increase the risk of bone fracture and leading to high morbidity. Dipsaci Radix (DR), one typical… read more here.
Keywords: systems pharmacology; pharmacology; action mechanisms; dipsaci radix ... See more keywords
Improving the generation and selection of virtual populations in quantitative systems pharmacology models.
Sign Up to like & getrecommendations! Published in 2018 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2018.06.002
Abstract: Quantitative systems pharmacology (QSP) models aim to describe mechanistically the pathophysiology of disease and predict the effects of therapies on that disease. For most drug development applications, it is important to predict not only the… read more here.
Keywords: qsp models; systems pharmacology; pharmacology; improving generation ... See more keywords
Systems pharmacology-based investigation of Sanwei Ganjiang Prescription: related mechanisms in liver injury.
Sign Up to like & getrecommendations! Published in 2018 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(18)30115-8
Abstract: Liver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang… read more here.
Keywords: sanwei ganjiang; systems pharmacology; ganjiang prescription; pharmacology ... See more keywords
Quantitative and Systems Pharmacology. 1. In Silico Prediction of Drug-Target Interactions of Natural Products Enables New Targeted Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00216
Abstract: Natural products with diverse chemical scaffolds have been recognized as an invaluable source of compounds in drug discovery and development. However, systematic identification of drug targets for natural products at the human proteome level via… read more here.
Keywords: natural products; pharmacology; drug target; systems pharmacology ... See more keywords
Dissection of Pharmacological Mechanism of Chinese Herbal Medicine Yihuo Huatan Formula on Chronic Obstructive Pulmonary Disease: A Systems Pharmacology-Based Study
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-50064-9
Abstract: Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases. Yihuo Huatan Formula (YHF), as a proven Chinese Herbal Medicine (CHM), has been verified to be effective in the treatment of stable… read more here.
Keywords: medicine; mechanism; systems pharmacology; copd ... See more keywords
Exploring the biomarkers and therapeutic mechanism of kidney-yang deficiency syndrome treated by You-gui pill using systems pharmacology and serum metabonomics
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c7ra12451a
Abstract: In this study, systems pharmacology was used to predict the molecular targets of You-gui pill (YGP) and explore the therapeutic mechanism of Kidney-Yang Deficiency Syndrome (KYDS) treated with YGP. On the basis of this, serum… read more here.
Keywords: gui pill; metabolism; systems pharmacology; serum ... See more keywords
Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2156317
Abstract: ABSTRACT Receptor occupancy assays applied in clinical studies provide insights into pharmacokinetic-pharmacodynamic relationships for therapeutic antibodies. When measured by different assays, however, receptor occupancy results can be controversial, as was observed for nivolumab, a monoclonal… read more here.
Keywords: systems pharmacology; pharmacology; quantitative systems; receptor occupancy ... See more keywords