Proteomics in systems toxicology.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2021.03.001
Abstract: Proteins are the ultimate product of gene expression. As they hinge between gene transcription and phenotype, they offer a more realistic perspective of toxicopathic effects, responses and even susceptibility to insult than targeting genes and… read more here.
Keywords: toxicology; pathology; biology; proteomics systems ... See more keywords
Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00499
Abstract: Omics data have been increasingly generated with limited demonstrated value in drug safety assessment. The TransQST consortium was launched to use omics and other data in mechanistic-based quantitative systems toxicology (QST) models to evaluate their… read more here.
Keywords: safety; drug; transqst consortium; systems toxicology ... See more keywords