Synaptotagmin‐11 Is a novel hotspot in the pathogenesis of parkin‐linked Parkinson's disease: New implications for clinical targeting
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27369
Abstract: Of several identified loci, Syt-11, the encoding gene for synaptotagmin-11, is of the hottest PD risk genes. Syt-11 is a non-Ca-binding Syt and cause the inhibition of neural endocytosis and therefor vesicle recycling. Of note,… read more here.
Keywords: accumulation; wang colleagues; syt; endocytosis ... See more keywords
Involvement of SNARE Protein Interaction for Non-classical Release of DAMPs/Alarmins Proteins, Prothymosin Alpha and S100A13
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00950-y
Abstract: Prothymosin alpha (ProTα) is involved in multiple cellular processes. Upon serum-free stress, ProTα lacking a signal peptide sequence is non-classically released from C6 glioma cells as a complex with Ca 2+ -binding cargo protein S100A13.… read more here.
Keywords: snare; syt; serum free; s100a13 ... See more keywords
Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b00468
Abstract: Synaptotagmin (Syt) is a membrane-associated protein involved in vesicle fusion through the SNARE complex that is found throughout the human body in 17 different isoforms. These isoforms have two membrane-binding C2 domains, which sense Ca2+… read more here.
Keywords: differential membrane; binding mechanics; membrane binding; syt ... See more keywords
Synaptotagmin-7 Enhances Facilitation of Cav2.1 Calcium Channels
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0081-22.2022
Abstract: Visual Abstract Voltage-gated calcium channel Cav2.1 undergoes Ca2+-dependent facilitation and inactivation, which are important in short-term synaptic plasticity. In presynaptic terminals, Cav2.1 forms large protein complexes that include synaptotagmins. Synaptotagmin-7 (Syt-7) is essential to mediate… read more here.
Keywords: interaction; enhances facilitation; cav2; facilitation ... See more keywords
Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Future oncology"
DOI: 10.2217/fon-2020-0262
Abstract: Aim: To explore the prognostic significance of Syt-7 in hepatocellular carcinoma (HCC) and the potential mechanisms. Methods: Immunohistochemistry was used to examine the expression of Syt-7. Overall survival and disease-free survival were compared between Syt-7… read more here.
Keywords: hepatocellular carcinoma; syt; syt overexpression; proliferation ... See more keywords
Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I
Sign Up to like & getrecommendations! Published in 2017 at "PeerJ"
DOI: 10.7717/peerj.2973
Abstract: Synaptotagmin I (Syt I) is most abundant in the brain and is involved in multiple cellular processes. Its two C2 domains, C2A and C2B, are the main functional regions. Our present study employed a pull-down… read more here.
Keywords: pull combined; combined proteomic; diversity; functional diversity ... See more keywords