Deficiency of synaptotagmin-1 aggravates pressure overload-induced cardiac hypertrophy and dysfunction via the p38 MAPK signaling pathway in mice
Sign Up to like & getrecommendations! Published in 2025 at "Human Cell"
DOI: 10.1007/s13577-025-01220-z
Abstract: Cardiac hypertrophy is a major risk factor for heart failure and sudden cardiac death, but its molecular mechanisms have not been well clarified. Synaptotagmin-1 (SYT1) is an important regulator of exocytosis and apoptosis and has… read more here.
Keywords: cardiac hypertrophy; hypertrophy; p38 mapk; syt1 ... See more keywords
SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling
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DOI: 10.1111/jnc.16186
Abstract: Following exocytosis, the recapture of plasma membrane‐stranded vesicular proteins into recycling synaptic vesicles (SVs) is essential for sustaining neurotransmission. Surface clustering of vesicular proteins has been proposed to act as a ‘pre‐assembly’ mechanism for endocytosis… read more here.
Keywords: syt1 synaptic; recruitment; sv2a; syt1 ... See more keywords
Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins
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DOI: 10.3390/molecules28104033
Abstract: Extended-synaptotagmin 1 (E-Syt1) is an endoplasmic reticulum membrane protein that is involved in cellular lipid transport. Our previous study identified E-Syt1 as a key factor for the unconventional protein secretion of cytoplasmic proteins in liver… read more here.
Keywords: liver cancer; secretion; syt1; extended synaptotagmin ... See more keywords