Microbiota-activated CD103+ DCs stemming from microbiota adaptation specifically drive γδT17 proliferation and activation
Sign Up to like & getrecommendations! Published in 2017 at "Microbiome"
DOI: 10.1186/s40168-017-0263-9
Abstract: BackgroundIL-17-producing γδT cells (γδT17) promote autoinflammatory diseases and cancers. Yet, γδT17 peripheral regulation has not been thoroughly explored especially in the context of microbiota-host interaction. The potent antigen-presenting CD103+ dendritic cell (DC) is a key… read more here.
Keywords: cd103 dcs; microbiota; t17; activated cd103 ... See more keywords
Regulation of γδT17 cells by Mycobacterium vaccae through interference with Notch/Jagged1 signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20209551
Abstract: The objective of this study was to investigate the effect of Mycobacterium vaccae on Jagged 1 and gamma delta T17 (γδT17) cells in asthmatic mice. An asthma mouse model was established through immunization with ovalbumin… read more here.
Keywords: notch; vaccae; t17 cells; t17 ... See more keywords
Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1045881
Abstract: The γδT cells that produce IL-17 (γδT17 cells) play a key role in various pathophysiologic processes in host defense and homeostasis. The development of γδT cells in the thymus requires γδT cell receptor (γδTCR) signaling… read more here.
Keywords: cell; required cell; tcr signaling; tyrosine kinase ... See more keywords