T1AM-TAAR1 signalling protects against OGD-induced synaptic dysfunction in the entorhinal cortex
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105271
Abstract: Abnormalities in thyroid hormones (TH) availability and/or metabolism have been hypothesized to contribute to Alzheimer's disease (AD) and to be a risk factor for stroke. Recently, 3-iodothyronamine (T1AM), an endogenous amine putatively derived from TH… read more here.
Keywords: entorhinal cortex; t1am; induced synaptic; effect ... See more keywords
Recovery of 3-Iodothyronamine and Derivatives in Biological Matrixes: Problems and Pitfalls
Sign Up to like & getrecommendations! Published in 2017 at "Thyroid"
DOI: 10.1089/thy.2017.0111
Abstract: Background: Difficulties have been reported in quantitating 3-iodothyronamine (T1AM) in blood or serum, and tentatively attributed to problems in extraction or other pre-analytical steps. For this reason, even cell culture experiments have often be performed… read more here.
Keywords: recovery iodothyronamine; t1am; cell culture; iodothyronamine ... See more keywords
T1AM Attenuates the Hypoxia/Reoxygenation-Induced Necroptosis of H9C2 Cardiomyocytes via RIPK1/RIPK3 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/4833791
Abstract: Purpose To investigate the detailed mechanism of 3-iodothyronamine (T1AM) in cell apoptosis and programmed necrosis of hypoxia/reoxygenation- (H/R-) induced H9C2 injury. Materials and Methods Cardiomyocyte H9C2 cells were cultured in vitro for the establishment of… read more here.
Keywords: group; necroptosis; ripk1 ripk3; t1am ... See more keywords
Torpor: The Rise and Fall of 3-Monoiodothyronamine from Brain to Gut—From Gut to Brain?
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2017.00118
Abstract: 3-Monoiodothyronamine (T1AM), first isolated from rat brain, is reported to be an endogenous, rapidly acting metabolite of thyroxine. One of its numerous effects is the induction of a “torpor-like” state in experimental animals. A critical… read more here.
Keywords: monoiodothyronamine; gut; t1am; rise fall ... See more keywords
3-Iodothyronamine Affects Thermogenic Substrates’ Mobilization in Brown Adipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Biology"
DOI: 10.3390/biology9050095
Abstract: We investigated the effect of 3-iodothyronamine (T1AM) on thermogenic substrates in brown adipocytes (BAs). BAs isolated from the stromal fraction of rat brown adipose tissue were exposed to an adipogenic medium containing insulin in the… read more here.
Keywords: insulin; akt; t1am; thermogenic substrates ... See more keywords
Redox Properties of 3-Iodothyronamine (T1AM) and 3-Iodothyroacetic Acid (TA1)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052718
Abstract: 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1) are thyroid-hormone-related compounds endowed with pharmacological activity through mechanisms that remain elusive. Some evidence suggests that they may have redox features. We assessed the chemical activity of T1AM and… read more here.
Keywords: mao; t1am; ta1; t1am iodothyroacetic ... See more keywords
Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12060476
Abstract: We examined relationships between thyroid hormone (TH) metabolites in humans by measuring 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM) levels after liothyronine administration. In secondary analyses, we measured 3,5-T2 and 3-T1AM concentrations in stored samples from two… read more here.
Keywords: administration; t1am; clinical trials; liothyronine administration ... See more keywords
Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26061616
Abstract: Recent reports highlighted the significant neuroprotective effects of thyronamines (TAMs), a class of endogenous thyroid hormone derivatives. In particular, 3-iodothyronamine (T1AM) has been shown to play a pleiotropic role in neurodegeneration by modulating energy metabolism… read more here.
Keywords: delivery thyronamines; t1am; thyronamines tams; study ... See more keywords