Incidence and trend of type 1 diabetes and the underlying environmental determinants
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3075
Abstract: A wealth of epidemiological studies concerning the distribution of type 1 diabetes (T1D) around the world have pointed to the appreciable variation in the incidence of T1D among disparate age groups, ethnicities, and geographical locations.… read more here.
Keywords: incidence; t1d; t1d incidence; incidence trend ... See more keywords
Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22521
Abstract: Polygenic risk scores (PRS) quantify the genetic liability to disease and are calculated using an individual's genotype profile and disease‐specific genome‐wide association study (GWAS) summary statistics. Type 1 (T1D) and type 2 (T2D) diabetes both… read more here.
Keywords: t1d t2d; risk scores; polygenic risk; t1d ... See more keywords
Metformin as an add-on to insulin improves periodontal response during orthodontic tooth movement in type 1 diabetic rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0140
Abstract: BACKGROUND Type 1 diabetes (T1D) is associated with delayed tissue healing and bone loss. Periodontal tissues during tooth movement (OTM) in T1D and under diabetic treatment are poorly understood. We aimed to study the effect… read more here.
Keywords: t1d; insulin; add insulin; tooth movement ... See more keywords
T1D‐weighted ihMT imaging – Part I. Isolation of long‐ and short‐T1D components by T1D‐filtering
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29139
Abstract: To identify T1D‐filtering methods, which can specifically isolate various ranges of T1D components as they may be sensitive to different microstructural properties. read more here.
Keywords: t1d weighted; t1d filtering; t1d; ihmt imaging ... See more keywords
T1D‐weighted ihMT imaging – Part II. Investigating the long‐ and short‐T1D components correlation with myelin content. Comparison with R1 and the macromolecular proton fraction
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29140
Abstract: To investigate the long‐ and short‐T1D components correlation with myelin content using inhomogeneous magnetization transfer (ihMT) high‐pass and band‐pass T1D‐filters and to compare ihMT, R1, and the macromolecular proton fraction (MPF) for myelin specific imaging. read more here.
Keywords: correlation myelin; short t1d; t1d; t1d components ... See more keywords
Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Immunogenetics"
DOI: 10.1007/s00251-017-0999-1
Abstract: Several lines of evidence show that autoimmune responses evolving in type 1 diabetes (T1D) patients include the generation of multi-reactive autoantibody (AutoAb) repertoires, but their role in T1D pathogenesis remains elusive. We tested the hypothesis… read more here.
Keywords: autoantibody; t1d; association; reactivity ... See more keywords
Genetic overlap between type 1 diabetes and other autoimmune diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in immunopathology"
DOI: 10.1007/s00281-021-00885-6
Abstract: Type 1 diabetes (T1D) is a chronic disease caused by the destruction of pancreatic β cells, which is driven by autoreactive T lymphocytes. It has been described that a high proportion of T1D patients develop… read more here.
Keywords: t1d; genetic overlap; autoimmune diseases; type diabetes ... See more keywords
Authors’ response to the commentary by Bonaventura and Montecucco on: ‘Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years after diabetes diagnosis’
Sign Up to like & getrecommendations! Published in 2018 at "Acta Diabetologica"
DOI: 10.1007/s00592-018-1226-8
Abstract: We would like to respond to the stimulating commentary by Dr. Bonaventura and Dr. Montecucco [1] on our article ‘Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years… read more here.
Keywords: commentary bonaventura; t1d; response; diagnosis ... See more keywords
The β-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Current Diabetes Reports"
DOI: 10.1007/s11892-020-01370-4
Abstract: Purpose of Review Type 1 diabetes (T1D) develops as a consequence of a combination of genetic predisposition and environmental factors. Combined, these events trigger an autoimmune disease that results in progressive loss of pancreatic β… read more here.
Keywords: t1d; cell genomic; t1d risk; pathogenesis ... See more keywords
Gene silencing of ZnT8 attenuates inflammation and protects pancreatic tissue injury in T1D.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2018.03.013
Abstract: T lymphocyte mediated inflammation contributes to the development of T1D. Zinc Transporter 8 (ZnT8) has emerged as a target of autoreactive T cells in human T1D in recent years. However, the regulating of ZnT8 in… read more here.
Keywords: tissue injury; t1d; pancreatic tissue; znt8 ... See more keywords
Association of prevalent vaginal microbiome of mother with occurrence of type I diabetes in child
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-37467-w
Abstract: Type I diabetes (T1D) is a rapidly increasing autoimmune disease especially in the Western countries and poses a serious global health problem. Incidence of T1D cannot be fully explained by genetic background, and environmental factors… read more here.
Keywords: t1d; vaginal microbiome; microbiome; type diabetes ... See more keywords