APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01454-5
Abstract: Trisomy 21 (T21) causes Down syndrome and an early-onset form of Alzheimer’s disease (AD). Here, we used human induced pluripotent stem cells (hiPSCs) along with CRISPR-Cas9 gene editing to investigate the contribution of chromosome 21… read more here.
Keywords: app dyrk1a; t21; pathology; synaptic vesicle ... See more keywords
Effective Fetal Epigenetic Biomarkers for Noninvasive Fetal Trisomy 21 Detections
Sign Up to like & getrecommendations! Published in 2018 at "Fetal Diagnosis and Therapy"
DOI: 10.1159/000494054
Abstract: Introduction: Recently, we identified three novel fetal-specific epigenetic DNA regions (FSERs) on chromosome 21 for detection of noninvasive fetal trisomy 21 (T21). In this study, the diagnostic accuracies of the three FSERs were assessed on… read more here.
Keywords: fetal trisomy; pregnant women; noninvasive fetal; t21 ... See more keywords
Abstract 15776: Outcomes of Atrioventricular Septal Defects in Patients With and Without Trisomy 21: Analysis of the Inpatient Sample Database
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DOI: 10.1161/circ.142.suppl_3.15776
Abstract: Introduction: Atrioventricular septal defect (AVSD) is among the most common congenital heart diseases especially in infants with trisomy 21 (T21). However, the clinical outcomes of AVSD are largely limited to institutional reports. Aim: Using U.S.A.… read more here.
Keywords: database; without t21; t21; mortality ... See more keywords
The Natural-Based Antitumor Compound T21 Decreases Survivin Levels through Potent STAT3 Inhibition in Lung Cancer Models
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DOI: 10.3390/biom9080361
Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide; hence novel treatments for this malignancy are eagerly needed. Since natural-based compounds represent a rich source of novel chemical entities in drug discovery, we have… read more here.
Keywords: inhibition; compound; lung cancer; cancer ... See more keywords