Toll-Like Receptor 2 Antagonist Ameliorates Type 2 Diabetes Mellitus Associated Neuropathic Pain by Repolarizing Pro-inflammatory Macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03365-3
Abstract: Diabetic neuropathy is one of the common complications of type 2 diabetes mellitus (T2DM) with severe outcomes. The mechanisms of physiopathology of diabetic neuropathy are not well elucidated. Inflammation and inflammatory macrophages are recognized to… read more here.
Keywords: inflammatory macrophages; t2dm mice; pro inflammatory; diabetic neuropathy ... See more keywords
Therapy of empagliflozin plus metformin on T2DM mice shows no higher amelioration for glucose and lipid metabolism than empagliflozin monotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116622
Abstract: AIMS This study was designed to compare the effects of empagliflozin monotherapy and its combination with metformin on glucose and lipid modulations in T2DM mice. MAIN METHODS Nine-week-old male C57BLKS/J db/db mice (n = 32) were used… read more here.
Keywords: empagliflozin monotherapy; glucose lipid; group; t2dm mice ... See more keywords
Aronia melanocarpa Anthocyanin Extracts Improve Hepatic Structure and Function in High-Fat Diet-/Streptozotocin-Induced T2DM Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03286
Abstract: Anthocyanins can prevent and ameliorate type 2 diabetes mellitus (T2DM), but its mechanism of action has not been fully established. IKK/NF-κB and JAK/Stat pathways have multiple effects, triggering T2DM. Liver abnormalities in individuals with T2DM… read more here.
Keywords: t2dm mice; high fat; diet streptozotocin; mice ... See more keywords
LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c02371
Abstract: Type 2 diabetes mellitus (T2DM) commonly affects bone quality at different hierarchical levels and leads to an increase in the risk of bone fracture. Earlier, some anti-diabetic drugs showed positive effects on bone mechanical properties.… read more here.
Keywords: t2dm mice; mice bone; bone; ldn ... See more keywords
MiR-503-5p alleviates peripheral neuropathy-induced neuropathic pain in T2DM mice by regulating SEPT9 to inhibit astrocyte activation
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-65096-z
Abstract: Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM) that causes peripheral and autonomic nervous system dysfunction. Dysregulation of miRNAs plays a crucial role in DPN development. However, the role… read more here.
Keywords: mice; protein; mir 503; t2dm mice ... See more keywords
Interplay between gut microbiota and tryptophan metabolism in type 2 diabetic mice treated with metformin
Sign Up to like & getrecommendations! Published in 2024 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00291-24
Abstract: ABSTRACT Tryptophan (TRP) metabolites have been identified as potent biomarkers for complications of type 2 diabetes mellitus (T2DM). However, it remains unclear whether the therapeutic effect of metformin in T2DM is related to the modulation… read more here.
Keywords: mice; gut microbiota; gut; t2dm mice ... See more keywords
IL-22 produced by type 3 innate lymphoid cells (ILC3s) reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008140
Abstract: Previously, we found that pathological immune responses enhance the mortality rate of Mycobacterium tuberculosis (Mtb)-infected mice with type 2 diabetes mellitus (T2DM). In the current study, we evaluated the role of the cytokine IL-22 (known… read more here.
Keywords: mice infected; t2dm mice; mtb infected; mortality ... See more keywords
Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1503807
Abstract: Aims Individuals with type 2 diabetes mellitus (T2DM) are at-risk for developing vascular dementia (VaD). Hyperglycemia leads to the activation of astrocytes. These activated cells produce proinflammatory mediators like cytokines or chemokines, that cause cerebrovascular… read more here.
Keywords: t2dm; hippocampal inflammation; t2dm mice; gene ... See more keywords
Astragaloside IV supplementation attenuates cognitive impairment by inhibiting neuroinflammation and oxidative stress in type 2 diabetic mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1004557
Abstract: Although diabetic cognitive impairment is one of the most common complications of type 2 diabetes mellitus (T2DM), optimized therapeutic strategies are not available yet. Astragalosides IV (AS-IV) is a traditional Chinese medicine possessing diverse pharmacological… read more here.
Keywords: cognitive impairment; oxidative stress; t2dm mice; mice ... See more keywords
Protopanaxadiol and Protopanaxatriol-Type Saponins Ameliorate Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus in High-Fat Diet/Streptozocin-Induced Mice
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00506
Abstract: Ginsenoside is a major active component of ginseng, which exhibits various pharmacological properties such as hepatoprotection, tumor suppression and diabetes resistance. In this study, the anti-diabetic effects of protopanaxadiol (PPD) and protopanaxatriol (PPT)-type saponins were… read more here.
Keywords: ppd ppt; ppt; metabolism; t2dm mice ... See more keywords
Effects of Frost Mulberry Leaf Superfine Powder on the Hypoglycemic and Gut Microbiota of High-Fat Diet/Streptozotocin-Induced Type 2 Diabetes Mellitus Mice
Sign Up to like & getrecommendations! Published in 2025 at "Applied Sciences"
DOI: 10.3390/app15073766
Abstract: Frost mulberry leaves possess significant medicinal and nutritional values and feature extensive resource availability and convenient acquisition. The study investigated the physicochemical structure and functional properties of frost mulberry leaf superfine powder (FMLSP) and the… read more here.
Keywords: gut microbiota; frost mulberry; gut; fmlsp ... See more keywords