Differentiation of imatinib -resistant chronic myeloid leukemia cells with BCR-ABL-T315I mutation induced by Jiyuan Oridonin A
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DOI: 10.7150/jca.83219
Abstract: Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. T315I mutated BCR-ABL is the main cause of the resistance mediated by imatinib and second generation… read more here.
Keywords: abl t315i; imatinib resistant; bcr abl; differentiation ... See more keywords