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   Articles with "t3ss" as a keyword



Novel pyrimidin-4-one derivatives as potential T3SS inhibitors against Xanthomonas campestris pv. campestris.

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recommendations! Published in 2023 at "Pest management science"

DOI: 10.1002/ps.7545

Abstract: BACKGROUND Cruciferous black rot is caused by Xanthomonas campestris pv. campestris (Xcc) infection and is a widespread disease worldwide. Excessive and repeated use of bactericide is an important cause of the development of bacterial resistance.… read more here.

Keywords: t3ss inhibitors; campestris campestris; novel; xanthomonas campestris ... See more keywords

LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-16169-w

Abstract: Many bacteria employ a type III secretion system (T3SS) injectisome to translocate proteins into eukaryotic host cells. Although the T3SS can efficiently export heterologous cargo proteins, a lack of target cell specificity currently limits its… read more here.

Keywords: t3ss; litesec t3ss; spatial temporal; eukaryotic cells ... See more keywords

Usurping bacterial virulence factors as self-delivery vehicles for therapeutic use

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recommendations! Published in 2017 at "Virulence"

DOI: 10.1080/21505594.2017.1336595

Abstract: Type III secretion systems (T3SS) as virulence factors were initially discovered in Yersinia and are now widely recognized in many bacterial pathogens that infect animals and plants. It was observed about 20 y ago that… read more here.

Keywords: t3ss; virulence; delivery; virulence factors ... See more keywords

Yersinia actively downregulates type III secretion and adhesion at higher cell densities

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recommendations! Published in 2025 at "PLOS Pathogens"

DOI: 10.1101/2024.06.27.601021

Abstract: The T3SS injectisome is used by Gram-negative bacteria, including important pathogens, to manipulate eukaryotic target cells by injecting effector proteins. While in some bacterial species, T3SS-negative bacteria benefit from the activity of their T3SS-positive siblings,… read more here.

Keywords: higher cell; yersinia actively; adhesion; cell ... See more keywords

Diversity of bradyrhizobial T3SS systems and their roles in symbiosis with peanut (Arachis hypogaea) and Vigna species (V. radiata and V. mungo)

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recommendations! Published in 2025 at "Applied and Environmental Microbiology"

DOI: 10.1128/aem.00600-25

Abstract: ABSTRACT Symbiosis between Bradyrhizobium strains isolated from Lao People’s Democratic Republic (Lao PDR) and intercropped legumes (Arachis hypogaea, Vigna radiata, and V. mungo) was regulated by the type III secretion system (T3SS), which delivers effector… read more here.

Keywords: nodulation; host; symbiosis; radiata mungo ... See more keywords

Quorum sensing employs a dual regulatory mechanism to repress T3SS gene expression

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recommendations! Published in 2025 at "mBio"

DOI: 10.1128/mbio.00106-25

Abstract: ABSTRACT The type III secretion system (T3SS) is a needle-like complex used by numerous bacterial pathogens in host infection to inject exotoxins into the host cell cytoplasm. The T3SS is a known virulence factor in… read more here.

Keywords: transcription; t3ss; expression; gene ... See more keywords

The Pseudomonas aeruginosa T3SS can contribute to traversal of an in situ epithelial multilayer independently of the T3SS needle

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recommendations! Published in 2025 at "mBio"

DOI: 10.1128/mbio.00266-25

Abstract: ABSTRACT Multilayered epithelia lining our tissue surfaces normally resist traversal by opportunistic bacteria. Previously, we developed a strategy to experimentally perturb this resistance in situ in the corneas of mouse eyes and used it to… read more here.

Keywords: independently t3ss; t3ss needle; culture; effector ... See more keywords
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BopN is a Gatekeeper of the Bordetella Type III Secretion System

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recommendations! Published in 2023 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.04112-22

Abstract: The T3SS is utilized by many Gram-negative bacteria to deliver effector proteins from bacterial cytosol directly into infected host cell cytoplasm in a regulated and targeted manner. Pathogenic bordetellae use the T3SS to inject the… read more here.

Keywords: bordetella; btea; secretion; host ... See more keywords

The quorum sensing regulator RhlR positively controls the expression of the type III secretion system in Pseudomonas aeruginosa PAO1

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recommendations! Published in 2024 at "PLOS ONE"

DOI: 10.1371/journal.pone.0307174

Abstract: Pseudomonas aeruginosa is an opportunist bacterium that causes acute and chronic infections. During acute infections, the type III secretion system (T3SS) plays a pivotal role in allowing the bacteria to translocate effectors such as ExoS,… read more here.

Keywords: system; regulator; pseudomonas aeruginosa; t3ss ... See more keywords
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Ancient co-option of an amino acid ABC transporter locus in Pseudomonas syringae for host signal-dependent virulence gene regulation

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recommendations! Published in 2020 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1008680

Abstract: Pathogenic bacteria frequently acquire virulence traits via horizontal gene transfer, yet additional evolutionary innovations may be necessary to integrate newly acquired genes into existing regulatory pathways. The plant bacterial pathogen Pseudomonas syringae relies on a… read more here.

Keywords: t3ss; amino acid; virulence; pseudomonas syringae ... See more keywords

A ParDE toxin–antitoxin system is responsible for the maintenance of the Yersinia virulence plasmid but not for type III secretion-associated growth inhibition

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recommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2023.1166077

Abstract: Many Gram-negative pathogens utilize the type III secretion system (T3SS) to translocate virulence-promoting effector proteins into eukaryotic host cells. The activity of this system results in a severe reduction of bacterial growth and division, summarized… read more here.

Keywords: system; growth; virulence plasmid; virulence ... See more keywords