In Vitro and In Silico Study to Assess Toxic Mechanisms of Hybrid Molecules of Quinone-Benzocaine as Plastoquinone Analogues in Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03428
Abstract: We managed to obtain three different series of 2,3-dimethyl-1,4-benzoquinones, named nonhalogenated and halogenated (brominated and chlorinated) PQ analogues, via the molecular hybridization strategy. Sixteen of eighteen hybrid molecules were selected by the National Cancer Institute… read more here.
Keywords: hybrid molecules; cell; cipq1; t47d ... See more keywords
Characterization of SN38-resistant T47D breast cancer cell sublines overexpressing BCRP, MRP1, MRP2, MRP3, and MRP4
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DOI: 10.1186/s12885-022-09446-y
Abstract: Background Although several novel resistant breast cancer cell lines have been established, only a few resistant breast cancer cell lines overexpress breast cancer resistance proteins ( BCRP ). The aim of this study was to… read more here.
Keywords: t47d; breast cancer; cancer cell; cancer ... See more keywords
RAD50 Deficient in a Breast Cancer Model Predicts Sensitivity to PARP Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Current cancer drug targets"
DOI: 10.2174/1568009623666230418101511
Abstract: BACKGROUND Breast and ovarian tumors with pathogenic variants in BRCA1 or BRCA2 genes are more sensitive to poly (ADP-ribose) polymerase inhibitors (PARPi) treatment than wild-type tumors. Pathogenic variants in non-BRCA1/2 homologous recombination repair genes (HRR)… read more here.
Keywords: breast cancer; t47d; rad50; rad50 deficient ... See more keywords