T618I CSF3R mutations in chronic neutrophilic leukemia induce oncogenic signals through aberrant trafficking and constitutive phosphorylation of the O-glycosylated receptor form.
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DOI: 10.1016/j.bbrc.2019.12.030
Abstract: Activating mutations in the membrane-proximal region of the colony-stimulating factor 3 receptor (CSF3R) are a hallmark of chronic neutrophilic leukemia (CNL) with the T618I mutation being most common. The mechanisms underlying constitutive activation of the… read more here.
Keywords: receptor; t618i csf3r; neutrophilic leukemia; chronic neutrophilic ... See more keywords