Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFRL858R/T790M inhibitors.
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DOI: 10.1016/j.ejmech.2018.11.069
Abstract: Third-generation epidermal growth factor receptor (EGFR)L858R/T790M inhibitors are still the main drugs for the treatment of advanced non-small cell lung cancer (NSCLC), and these drugs have achieved remarkable clinical efficacy. However, there are still many… read more here.
Keywords: design synthesis; t790m inhibitors; t790m; egfrl858r t790m ... See more keywords