Binding mechanism of kinase inhibitors to EGFR and T790M, L858R and L858R/T790M mutants through structural and energetic analysis.
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DOI: 10.1016/j.ijbiomac.2018.07.042
Abstract: Experimental studies have demonstrated that L858R mutation in the EGF receptor (EGFR) confers tumor sensitivity whereas T790M and L858R/T790M mutations cause resistance to tyrosine kinase inhibitors in patients with non-small cell lung cancer. Theoretical studies… read more here.
Keywords: egfr; l858r; analysis; t790m l858r ... See more keywords