Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics
Sign Up to like & getrecommendations! Published in 2021 at "Circulation. Heart Failure"
DOI: 10.1161/circheartfailure.121.009195
Abstract: Supplemental Digital Content is available in the text. Background: Current heart failure therapies unload the failing heart without targeting the underlying problem of reduced cardiac contractility. Traditional inotropes (ie, calcitropes) stimulate contractility via energetically costly… read more here.
Keywords: ta1; heart; contractile function; pressure ... See more keywords
Redox Properties of 3-Iodothyronamine (T1AM) and 3-Iodothyroacetic Acid (TA1)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052718
Abstract: 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1) are thyroid-hormone-related compounds endowed with pharmacological activity through mechanisms that remain elusive. Some evidence suggests that they may have redox features. We assessed the chemical activity of T1AM and… read more here.
Keywords: mao; t1am; ta1; t1am iodothyroacetic ... See more keywords
Hot Deformation Behavior of TA1 Prepared by Electron Beam Cold Hearth Melting with a Single Pass
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma16010369
Abstract: The Gleeble-3800 thermal simulator was used for hot compression simulation to understand the hot deformation performance of TA1 prepared by the single-pass electron beam cold hearth (EB) process. The deformation degree is 50% on a… read more here.
Keywords: deformation; single pass; ta1; ta1 prepared ... See more keywords