Role of Necroptosis and Immune Infiltration in Human Stanford Type A Aortic Dissection: Novel Insights from Bioinformatics Analyses
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DOI: 10.1155/2022/6184802
Abstract: Background Stanford type A aortic dissection (TAAD) is one of the most life-threatening cardiovascular emergencies with high mortality and morbidity, and necroptosis is a newly identified type of programmed cell death and contributes to the… read more here.
Keywords: infiltration; necroptosis; immune infiltration; role necroptosis ... See more keywords
MicroRNA-21 Knockout Exacerbates Angiotensin II–Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-&bgr;–SMAD3 Signaling
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DOI: 10.1161/atvbaha.117.310694
Abstract: Objective— Thoracic aortic aneurysm and dissection (TAAD) are severe vascular conditions. Dysfunctional transforming growth factor-&bgr; (TGF-&bgr;) signaling in vascular smooth muscle cells and elevated angiotensin II (AngII) levels are implicated in the development of TAAD.… read more here.
Keywords: bgr signaling; mir; taad; mice ... See more keywords
Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice
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DOI: 10.1161/atvbaha.122.318788
Abstract: Background: Thoracic aortic aneurysm and dissection (TAAD) is a highly lethal vascular disease without effective drug therapy. Whether elevated serum concentrations of uric acid are involved in TAAD development remains unclear. Methods: Serum uric acid… read more here.
Keywords: thoracic aortic; aortic aneurysm; urate lowering; mice ... See more keywords