Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.10.058
Abstract: Trace amines (TAs) are endogenous neuromodulators that play a functional role in the synaptic transmission within central nervous system (CNS), targeting trace amine-associated receptors (TAARs). Starting from our previous computational studies on TAAR1 and TAAR5… read more here.
Keywords: based derivatives; murine; biguanide based; taar1 agonists ... See more keywords
Opportunities and challenges in the design of selective TAAR1 agonists: an editorial
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2018.1476493
Abstract: Nowadays, compounds targeting G-protein-coupled receptors (GPCRs) represent a large amount of clinically relevant drugs, depicting a leading role in the drug discovery panorama. Trace amine-associated receptors (TAARs) belong to the family of GPCRs, whose first… read more here.
Keywords: design selective; challenges design; opportunities challenges; taar1 ... See more keywords