Universal Screening in Primary Care Practices by Self-administered Tablet vs Nursing Staff
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.1480
Abstract: This nonrandomized controlled trial investigates whether self-administered screening via an in-office tablet app was associated with improved detection of patients at risk for depression, injurious falls, or intimate partner violence compared with screening performed by… read more here.
Keywords: screening primary; care practices; tablet; self administered ... See more keywords
Tablet-Assisted Objective Structured Spotter Practical Examination (TOSSPE): Advantages of an innovative anatomy spotter examination method for medical student assessment.
Sign Up to like & getrecommendations! Published in 2021 at "Anatomical sciences education"
DOI: 10.1002/ase.2131
Abstract: The affordances of technology-based assessments, like the Objectively Structured Practical Examination, have become an integral part of gross anatomy courses. The Department of Anatomy Faculty of Medicine at the University of Warmia and Mazury developed… read more here.
Keywords: examination; practical examination; anatomy; method ... See more keywords
Relative Bioavailability and Food Effect of GSK3640254 Tablet and Capsule Formulations in Healthy Participants.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1051
Abstract: GSK3640254 is a next-generation maturation inhibitor with demonstrated potency across HIV-1 subtypes and a high barrier to emergent resistance. This phase I, 2-part, randomized, open-label study (ClinicalTrials.gov identifier, NCT04263142) in healthy participants assessed the relative… read more here.
Keywords: food; gsk3640254; healthy participants; part ... See more keywords
Bioequivalence of Esaxerenone Conventional Tablet and Orally Disintegrating Tablet: Two Single‐Dose Crossover Studies in Healthy Japanese Men
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1087
Abstract: We assessed the bioequivalence of a single dose of 5‐mg of esaxerenone administered as an orally disintegrating tablet (ODT) with the conventional oral tablet in healthy Japanese men. This single‐center, open‐label, randomized, two‐drug, two‐stage crossover,… read more here.
Keywords: single dose; orally disintegrating; tablet; disintegrating tablet ... See more keywords
Pharmacokinetics and Bioequivalence of a Generic and a Branded Pazopanib Tablet in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1096
Abstract: This study aimed to evaluate the bioequivalence of two pazopanib tablet formulations in healthy Chinese subjects. A randomized, open‐label, single‐dose, two‐period, two‐sequence, crossover study was conducted under fasting conditions. A total of 32 eligible subjects… read more here.
Keywords: pazopanib tablet; chinese subjects; tablet; generic branded ... See more keywords
Pharmacokinetics and Safety of Vibegron 75 mg Administered as an Intact or Crushed Tablet in Healthy Adults
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1169
Abstract: Oral pharmacotherapy for overactive bladder, a condition that increases with age, includes anticholinergics and β3‐adrenergic receptor agonists. Older adults, including those with dysphagia, may have difficulty swallowing tablets. In this phase 1 study in healthy… read more here.
Keywords: vibegron; pharmacokinetics safety; tablet; healthy adults ... See more keywords
Comparative Bioavailability of a Novel Solution and a Tablet Formulation of Levothyroxine
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1233
Abstract: Levothyroxine (LT4) is the standard of care for treating hypothyroidism. Despite the established efficacy of LT4, 50% of treated patients fail to achieve normal thyrotropin levels. Oral formulations of LT4 that bypass the gastric phase… read more here.
Keywords: bioavailability novel; tablet; concentration; levothyroxine ... See more keywords
A Bioequivalence Comparison Between the Once‐Daily Extended‐Release Tablet and the Twice‐Daily Tablet Formulations of Deutetrabenazine at Steady State
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1355
Abstract: Deutetrabenazine is approved for the treatment of tardive dyskinesia and chorea associated with Huntington's disease. This study compared the exposure between the once‐daily (test) and twice‐daily (reference) formulations of deutetrabenazine under fed conditions. Using a… read more here.
Keywords: tablet; formulations deutetrabenazine; twice daily; steady state ... See more keywords
Reduced Plasma Levodopa Fluctuations with More Frequent Administration of a Novel Carbidopa/Levodopa Functionally Scored Tablet
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DOI: 10.1002/cpdd.1360
Abstract: Levodopa/carbidopa remains the gold standard for treating Parkinson disease (PD), but chronic pulsatile administration contributes to motor complications. This Phase 1 study used a new immediate‐release (IR) formulation of carbidopa/levodopa 25/100 mg that is functionally… read more here.
Keywords: functionally scored; plasma levodopa; levodopa fluctuations; administration ... See more keywords
Taste Profile and Relative Bioavailability of Tovorafenib Powder for Oral Suspension and Food Effect of the Tovorafenib Tablet in Healthy Participants
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DOI: 10.1002/cpdd.1558
Abstract: A pediatric‐friendly powder for oral suspension (PfOS) of tovorafenib, a type II RAF inhibitor, was developed for patients with difficulty swallowing tablets. This open‐label, randomized, phase 1 study (QSC205140) evaluated the taste/palatability of PfOS formulations… read more here.
Keywords: relative bioavailability; food; powder oral; tablet ... See more keywords
Relative Bioavailability, Food Effect, and Bioequivalence Studies to Assess a New Zanubrutinib 160-mg Tablet: Results From 2 Phase 1 Studies in Healthy Volunteers.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1584
Abstract: Zanubrutinib is a next-generation Bruton tyrosine kinase inhibitor approved for treating B-cell malignancies. Two phase 1 studies evaluated a new 160-mg zanubrutinib tablet versus 80-mg capsules. In study BGB-3111-115 (n = 43), a randomized 3-period crossover trial,… read more here.
Keywords: relative bioavailability; food; bioavailability food; phase studies ... See more keywords