Pharmacokinetics of Tacrolimus Coadministered With Letermovir in Allogeneic Hematopoietic Stem Cell Transplantation Patients
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.669
Abstract: Kropeit et al reported drug-drug interactions between letermovir and the immunosuppressive agents cyclosporin A and tacrolimus (Tac) in healthy subjects.1 According to this report, maximum drug concentration (Cmax) of Tac or total exposure to Tac… read more here.
Keywords: administration; blood concentration; tac; drug ... See more keywords
Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of hepato-biliary-pancreatic sciences"
DOI: 10.1002/jhbp.1310
Abstract: BACKGROUND/PURPOSE This experimental study in rats aimed to investigate the impact of very early introduction (within 3 hours) of everolimus (EVR) + reduced-tacrolimus (TAC) after partial liver transplantation (LT) on liver regeneration, rejection, and survival.… read more here.
Keywords: liver; early introduction; tac; liver regeneration ... See more keywords
Carboxymethyl Cellulose-Coated Tacrolimus Nonspherical Microcrystals for Improved Therapeutic Efficacy of Dry Eye.
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202000079
Abstract: Dry eye (DE) is a highly prevalent ocular surface disease which affects the quality of life and results in low working efficiency. Frequent instillation is required due to low bioavailability of conventional eye drops. The… read more here.
Keywords: tac; cmc; carboxymethyl cellulose; tac mcs ... See more keywords
Relationship of Tacrolimus Concentration and Incidence of Acute Graft-Versus-Host Disease after Allogenic Stem Cell Transplantation
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.730
Abstract: Introduction Acute graft versus host disease (aGVHD) remains a leading cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HSCT). Preventing GVHD without impairing the graft-versus-tumor effect remains an important goal for successful… read more here.
Keywords: incidence; allo hsct; week; tac ... See more keywords
Emerging Role of the Mitochondrial Outer Membrane Translocator Protein (TSPO) in Heart Failure and Mitochondrai Quality Control
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1758
Abstract: Introduction: Mitochondrial dysfunction is a hallmark of heart failure (HF), resulting in decreased energy production and impaired mitochondrial quality control (mitophagy) with resultant contractile dysfunction and cell death. The 18-kDa mitochondrial translocator protein (TSPO) has… read more here.
Keywords: tac; heart failure; translocator protein; role ... See more keywords
Glycol chitosan-based renal docking biopolymeric nanomicelles for site-specific delivery of the immunosuppressant.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.116255
Abstract: In this study, we propose the use of glycol chitosan for the targeted delivery of hydrophobic drugs such as tacrolimus (TAC) towards the kidney. We synthesized a hydrophobically modified glycol chitosan (HGC) polymeric nanomicelle followed… read more here.
Keywords: tac; delivery; glycol chitosan; hgc tac ... See more keywords
Polyacrylic acid, a highly efficient dispersant for aqueous processing of tantalum carbide
Sign Up to like & getrecommendations! Published in 2017 at "Ceramics International"
DOI: 10.1016/j.ceramint.2016.11.205
Abstract: Abstract Polyacrylic acid (PAA) with three different molecular weights (PAA-3000, PAA-15000, PAA-100000) was used as a dispersant to investigate the aqueous dispersion behavior of commercially available TaC powder. TaC stabilized with PAA-3000 polymer showed the… read more here.
Keywords: tac; dispersant; paa 3000; polyacrylic acid ... See more keywords
Investigation on the ablation performance and mechanism of HfC coating modified with TaC
Sign Up to like & getrecommendations! Published in 2020 at "Corrosion Science"
DOI: 10.1016/j.corsci.2020.108649
Abstract: Abstract HfC coatings modified with different TaC contents were designed and successfully deposited on SiC-coated carbon/carbon (C/C) composites by supersonic atmosphere plasma spraying. The phase composition, morphology, and ablation resistance were surveyed, and the structural… read more here.
Keywords: performance mechanism; tac; ablation; ablation performance ... See more keywords
Improved tacrolimus skin permeation by coâencapsulation with clobetasol in lipid nanoparticles: Study of drug effects in lipid matrix by electron paramagnetic resonance
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.06.014
Abstract: Graphical abstract Figure. No Caption available. Abstract Combined therapy with corticosteroids and immunosuppressantâloaded nanostructured lipid carriers (NLC) could be useful in the treatment of skin diseases. To circumvent NLC loading capacity problems, loaded drugs should… read more here.
Keywords: tac; drug; clo; clo nlc ... See more keywords
Dual roles of TPGS based microemulsion for tacrolimus: Enhancing the percutaneous delivery and anti-psoriatic efficacy.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.06.050
Abstract: In this study, we demonstrate for the first time the dual roles of Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) based microemulsion (ME) for tacrolimus (TAC) to enhance TAC percutaneous delivery and anti-psoriatic efficacy. The ME… read more here.
Keywords: anti psoriatic; psoriatic efficacy; percutaneous delivery; tac ... See more keywords
Trauma assessment clinic: Virtually a safe and smarter way of managing trauma care in Ireland.
Sign Up to like & getrecommendations! Published in 2019 at "Injury"
DOI: 10.1016/j.injury.2019.03.046
Abstract: INTRODUCTION The Trauma Assessment Clinic [TAC], also referred to as Virtual Fracture Clinic, offers a novel care pathway for patients and is being increasingly utilised across the Irish and UK health care systems. The provision… read more here.
Keywords: tac; trauma assessment; trauma; care ... See more keywords