The role of TACC3 in mitotic spindle organization
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DOI: 10.1002/cm.21388
Abstract: TACC3 regulates spindle organization during mitosis and also regulates centrosome‐mediated microtubule nucleation by affecting γ‐Tubulin ring complexes. In addition, it interacts with different proteins (such as ch‐TOG, clathrin and Aurora‐A) to function in mitotic spindle… read more here.
Keywords: spindle organization; tacc3 mitotic; tog clathrin; mitotic spindle ... See more keywords
CORR Insights®: Elevated Expression of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) Is Associated With a Poor Prognosis in Osteosarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Orthopaedics and Related Research"
DOI: 10.1097/corr.0000000000000416
Abstract: Conventional primary osteosarcoma is the most-common malignant bone tumor. As an aggressive neoplasm, it often affects young individuals, potentially taking years off patients’ lives [6]. Standard chemotherapy and sophisticated surgical techniques have led to an… read more here.
Keywords: poor prognosis; transforming acidic; prognosis; osteosarcoma ... See more keywords
Elevated expression of transforming acidic coiled‐coil‐containing protein 3 (TACC3) reflects aggressiveness of primary central nervous system lymphomas
Sign Up to like & getrecommendations! Published in 2022 at "Pathology International"
DOI: 10.1111/pin.13264
Abstract: Transforming acidic coiled‐coil‐containing protein 3 (TACC3) plays an important role in centrosome/microtubule dynamics. Deregulation of centrosomes/microtubules causes mitotic spindle defects, leading to tumorigenesis. However, the correlation between TACC3 and primary central nervous system lymphomas (PCNSLs)… read more here.
Keywords: primary central; central nervous; expression; system lymphomas ... See more keywords
High Expression of TACC3 Is Associated with the Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma Patients
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DOI: 10.1155/2022/8789515
Abstract: Background Lung adenocarcinoma (LUAD) has been recognized as one of the commonest aggressive malignant tumors occurring in humans. The transforming acidic coiled-coil-containing protein 3 (TACC3) seems to be a probable prognostic marker and treatment target… read more here.
Keywords: expression; lung; analysis; tacc3 ... See more keywords
TACC3 as an independent prognostic marker for solid tumors: a systematic review and meta-analysis
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DOI: 10.18632/oncotarget.20466
Abstract: Recent studies have showed that the transforming acidic coiled coil 3 (TACC3), was aberrantly up-regulated in various solid tumors and was reported to be correlated with unfavorable prognosis in cancer patients. This study aimed to… read more here.
Keywords: expression; solid tumors; tacc3; meta analysis ... See more keywords
Glioblastoma, IDH-Wild Type With FGFR3-TACC3 Fusion: When Morphology May Reliably Predict the Molecular Profile of a Tumor. A Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.823015
Abstract: It has been reported that in-frame FGFR3-TACC3 fusions confer to glioblastomas, IDH-wild type (GBMs, IDHwt) some unusual morphologic features, including monomorphous rounded cells with ovoid nuclei, nuclear palisading, endocrinoid network of “chicken-wire” vessels, microcalcifications and… read more here.
Keywords: fusion; fgfr3 tacc3; morphology; tacc3 ... See more keywords