Tachykinin Neuropeptides and Amyloid β (25-35) Assembly: Friend or Foe?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03845
Abstract: Amyloid β (Aβ) protein is responsible for Alzheimer's disease, and one of its important fragments, Aβ(25-35), is found in the brain and has been shown to be neurotoxic. Tachykinin neuropeptides, including Neuromedin K (NK), Kassinin,… read more here.
Keywords: substance; tachykinin; tachykinin neuropeptides; neuropeptides amyloid ... See more keywords
The structural conformation of the tachykinin domain drives the anti‐tumoural activity of an octopus peptide in melanoma BRAFV600E
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15923
Abstract: Over past decades, targeted therapies and immunotherapy have improved survival and reduced the morbidity of patients with BRAF‐mutated melanoma. However, drug resistance and relapse hinder overall success. Therefore, there is an urgent need for novel… read more here.
Keywords: tachykinin; tachykinin domain; melanoma; peptide ... See more keywords
Targeting tachykinin receptors in neuroblastoma
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DOI: 10.18632/oncotarget.13440
Abstract: Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%. Adding targeted drugs to first-line therapy regimens is a promising approach… read more here.
Keywords: targeting tachykinin; cell lines; neuroblastoma; tachykinin receptor ... See more keywords