Structure–activity relationship of tacrine and its analogues in relation to inhibitory activity against Alzheimer’s disease
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DOI: 10.1007/s00894-019-3993-8
Abstract: AbstractAlzheimer’s disease is a widespread type of neurodegenerative dementia that mainly affects the elderly. Currently, this disease can only be treated palliatively. Existing drugs can only improve patients’ symptoms. The search for new drugs that… read more here.
Keywords: alzheimer disease; activity; structure activity; tacrine analogues ... See more keywords
Therapeutic Potential of Multifunctional Tacrine Analogues
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DOI: 10.2174/1570159x16666180412091908
Abstract: Abstract: Tacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in… read more here.
Keywords: therapeutic potential; tacrine analogues; tacrine; alzheimer disease ... See more keywords