Novel diarylated tacrine derivatives: Synthesis, characterization, anticancer, antiepileptic, antibacterial, and antifungal activities
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DOI: 10.1002/jbt.23706
Abstract: In this study, our goal was to synthesize novel aryl tacrine derivatives and assess their potential as anticancer, antibacterial agents, and enzyme inhibitors. We adopted a two‐step approach, initiating with the synthesis of dibromotacrine derivatives… read more here.
Keywords: novel diarylated; anticancer; diarylated tacrine; characterization ... See more keywords
Cu-metal organic frameworks (Cu-MOF) as an environment-friendly and economical catalyst for one pot synthesis of tacrine derivatives
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DOI: 10.1039/c9ra10111j
Abstract: The present work describes the catalytic activity of Cu-MOF for the one-pot synthesis of tacrine derivatives via a four-component reaction of 2-hydroxynaphthalene-1,4-dione, aldehydes, malononitrile and cycloketones in the presence of AlCl3. The structure of the… read more here.
Keywords: pot synthesis; synthesis tacrine; one pot; tacrine derivatives ... See more keywords
Design, Synthesis and Molecular Modeling Study of Radiotracers Based on Tacrine and Its Derivatives for Study on Alzheimer’s Disease and Its Early Diagnosis
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DOI: 10.3390/app14072827
Abstract: From 1993 to 2013, tacrine was an approved drug for Alzheimer’s disease. Due to its strong inhibitory properties towards cholinesterase, tacrine causes an increase in the level of the neurotransmitter acetylcholine in the cholinergic system… read more here.
Keywords: alzheimer disease; diagnosis; based tacrine; tacrine derivatives ... See more keywords
QSAR Studies Regarding Some Not Yet Synthesized Tacrine Derivatives
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DOI: 10.37358/rc.19.8.7491
Abstract: In QSAR study #1 the analyzed group includes only 127 molecules in the calibration set (molecules having known value of the biochemical activity). There are six molecular fragments identified as favorable for a high value… read more here.
Keywords: set molecules; qsar; calibration set; tacrine derivatives ... See more keywords