Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives.
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DOI: 10.1016/j.bioorg.2019.103006
Abstract: A series of novel tacrine-isatin Schiff base hybrid derivatives (7a-p) were designed, synthesized and evaluated as multi-target candidates against Alzheimer's disease (AD). The biological assays indicated that most of these compounds displayed potent inhibitory activity… read more here.
Keywords: ache; tacrine isatin; isatin schiff; tacrine ... See more keywords