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Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103387
Abstract: We synthesized conjugates of tacrine with 1,2,4-thiadiazole derivatives linked by two different spacers, pentylaminopropene (compounds 4) and pentylaminopropane (compounds 5), as potential drugs for the treatment of Alzheimer's disease (AD). The conjugates effectively inhibited cholinesterases…
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Keywords:
alzheimer disease;
treatment;
tacrine thiadiazole;
thiadiazole derivatives ... See more keywords