Effect of Tacrolimus vs Intravenous Cyclophosphamide on Complete or Partial Response in Patients With Lupus Nephritis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.4492
Abstract: Key Points Question What is the efficacy and safety of tacrolimus vs intravenous cyclophosphamide (IVCY) as initial therapy for lupus nephritis (LN) among Chinese patients? Findings In this randomized clinical trial of 299 patients, the… read more here.
Keywords: tacrolimus intravenous; lupus nephritis; complete partial; tacrolimus ... See more keywords
Comparison between mono‐tacrolimus and mono‐glucocorticoid in the treatment of myasthenia gravis
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51746
Abstract: Use of tacrolimus in mild to moderate myasthenia gravis (MG) is generally limited to glucocorticoid‐refractory cases; the advantage of mono‐tacrolimus over mono‐glucocorticoids is unknown. read more here.
Keywords: tacrolimus; myasthenia gravis; tacrolimus mono; mono tacrolimus ... See more keywords
Identification of Factors Affecting Tacrolimus Trough Levels in Latin American Pediatric Liver Transplant Patients
Sign Up to like & getrecommendations! Published in 2019 at "Liver Transplantation"
DOI: 10.1002/lt.25495
Abstract: Tacrolimus is the cornerstone in pediatric liver transplant immunosuppression. Despite close monitoring, fluctuations in tacrolimus blood levels affect safety and efficacy of immunosuppressive treatments. Identifying the factors related to the variability in tacrolimus exposure may… read more here.
Keywords: transplant patients; liver; liver transplant; tacrolimus ... See more keywords
Reduced steroid-induced intraocular pressure elevation in tacrolimus-treated refractory allergic ocular diseases
Sign Up to like & getrecommendations! Published in 2020 at "Japanese Journal of Ophthalmology"
DOI: 10.1007/s10384-020-00774-9
Abstract: To determine whether topical tacrolimus can lessen steroid-induced intraocular pressure (IOP) elevation. Open cohort post hoc analysis study. Five hundred eleven patients with vernal keratoconjunctivitis or atopic keratoconjunctivitis (mean age 17.0 ± 9.2 years) were studied. All… read more here.
Keywords: tacrolimus treated; steroid induced; iop; elevation ... See more keywords
Role of FK506 Binding Protein on Tacrolimus Distribution in Red Blood Cells
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Research"
DOI: 10.1007/s11095-020-02875-z
Abstract: Purpose Tacrolimus is distributed mainly in red blood cells (RBCs) after transfer into blood. This study aimed to evaluate the effect of FK506-binding proteins (FKBPs) on RBC distribution of tacrolimus in a physiological environment. Methods… read more here.
Keywords: tacrolimus distribution; effect; blood; rbcs ... See more keywords
Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-024-01368-1
Abstract: High variability in tacrolimus pharmacokinetics directly after lung transplantation (LuTx) may increase the risk for acute kidney injury (AKI) and transplant rejection. The primary objective was to compare pharmacokinetic variability in patients receiving tacrolimus orally… read more here.
Keywords: tacrolimus; variability; group; intravenous administration ... See more keywords
A Population Pharmacokinetic Model and Dosing Algorithm to Guide the Tacrolimus Starting and Follow-Up Dose in Living and Deceased Donor Kidney Transplant Recipients
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-025-01533-0
Abstract: Tacrolimus treatment is complicated by its narrow therapeutic range and large inter- and intra-patient variability. This study aimed to develop a population pharmacokinetic model and dosing algorithm to predict an individual’s dose requirement following living… read more here.
Keywords: tacrolimus; living deceased; donor kidney; deceased donor ... See more keywords
Aqueous penetration of topical tacrolimus
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2019.100582
Abstract: Purpose To evaluate the penetration of topical tacrolimus 0.05% into the aqueous humor. Observations A total of four patients scheduled for routine cataract surgery were included prospectively. We excluded patients with corneal pathology or ocular… read more here.
Keywords: tacrolimus aqueous; penetration topical; aqueous humor; topical tacrolimus ... See more keywords
Use of Sublingual Tacrolimus in Adults Undergoing Hematopoietic Cell Transplant: A Pilot Study
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.315
Abstract: The national shortage of oral (PO) and intravenous (IV) tacrolimus, as well as the undesirable sequelae of IV administration, call for innovative solutions to conserve existing supply and optimize safety and efficacy of medication delivery.… read more here.
Keywords: undergoing hematopoietic; administration; ratio; hematopoietic cell ... See more keywords
Optimization of media and culture conditions for the production of tacrolimus by Streptomyces tsukubaensis in shake flask and fermenter level
Sign Up to like & getrecommendations! Published in 2020 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2020.101803
Abstract: Abstract Goal of present research based on optimization of tacrolimus production by One-factor-at-a-time method and response surface methodology (RSM) using Streptomyces tsukubaensis NBRC 108819. Plackett–Burman Design was adopted for the selection of main nutrients inducing… read more here.
Keywords: optimization; production tacrolimus; streptomyces tsukubaensis; tacrolimus production ... See more keywords
Twice-daily intravenous bolus tacrolimus infusion: A safe and effective regimen for graft-versus-host disease prophylaxis.
Sign Up to like & getrecommendations! Published in 2020 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2020.03.002
Abstract: OBJECTIVE/BACKGROUND Among patients undergoing allogeneic hematopoietic cell transplant, continuous intravenous (IV) tacrolimus infusion is frequently used for graft-versus-host disease (GvHD) prophylaxis. Twice-daily intermittent IV tacrolimus dosing may confer safety and convenience benefits. METHODS We performed… read more here.
Keywords: tacrolimus infusion; versus host; twice daily; host disease ... See more keywords