P-glycoprotein, FK-binding Protein-12, and the Intracellular Tacrolimus Concentration in T-lymphocytes and Monocytes of Kidney Transplant Recipients
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DOI: 10.1097/tp.0000000000004287
Abstract: Background . Transplant recipients may develop rejection despite having adequate tacrolimus whole blood predose concentrations (C0). The intra-immune cellular concentration is potentially a better target than C0. However, little is known regarding intracellular tacrolimus concentration… read more here.
Keywords: concentration lymphocytes; tacrolimus concentration; intracellular tacrolimus; concentration ... See more keywords
The stability of initial tacrolimus concentration following allogeneic hematopoietic stem cell transplantation reduces the risk of acute GVHD
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DOI: 10.1111/ctr.14052
Abstract: Early tacrolimus (TAC) concentrations correlate with the risk of acute graft‐versus‐host disease (aGVHD); however, whether the variability of early TAC concentrations after allo‐HSCT governs the occurrence of aGVHD remains unknown. Here, we evaluate the correlation… read more here.
Keywords: tacrolimus concentration; risk acute; initial tacrolimus; transplantation ... See more keywords
Adequate tacrolimus concentration for myasthenia gravis treatment
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DOI: 10.1111/ene.13189
Abstract: A single, oral dose of 3 mg/day tacrolimus, approved for myasthenia gravis (MG) treatment in Japan, was shown to reduce steroid dose and anti‐acetylcholine receptor (AChR) antibody titers as well as to improve MG symptoms.… read more here.
Keywords: tacrolimus concentration; treatment; gravis treatment; myasthenia gravis ... See more keywords
Tacrolimus Concentration Is Effectively Predicted Using Combined Clinical and Genetic Factors in the Perioperative Period of Kidney Transplantation and Associated with Acute Rejection
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DOI: 10.1155/2022/3129389
Abstract: Background Tacrolimus has unpredictable pharmacokinetic (PK) characteristics, which are partially attributed to CYP3A5 polymorphism. The potential effects of clinical factors in the postoperative period of transplantation on tacrolimus PK and those of early tacrolimus PK… read more here.
Keywords: clinical factors; tacrolimus concentration; kidney; transplantation ... See more keywords