Predictive Capacity of Population Pharmacokinetic Models for the Tacrolimus Dose Requirements of Pediatric Solid Organ Transplant Recipients
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DOI: 10.1097/ftd.0000000000001002
Abstract: Background: Transplant recipients require individualized tacrolimus doses to maximize graft survival. Multiple pediatric tacrolimus population pharmacokinetic (PopPK) models incorporating CYP3A5 genotype and other covariates have been developed. Identifying the optimal popPK model is necessary for… read more here.
Keywords: tacrolimus dose; transplant; model; transplant recipients ... See more keywords
Evaluating the Effects of Ertapenem and Meropenem on Tacrolimus.
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DOI: 10.1177/08971900221117627
Abstract: PURPOSE Further elucidate the potential drug interaction between tacrolimus and carbapenems in order to appropriately maintain the balance between infection treatment and therapeutic immunosuppression. METHODS This study was a retrospective evaluation of solid organ transplant… read more here.
Keywords: administration; median daily; ertapenem meropenem; daily tacrolimus ... See more keywords
Tacrolimus dose modification in patients receiving concomitant isavuconazole after hematopoietic stem cell transplantation
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DOI: 10.1177/1078155220940416
Abstract: Introduction Isavuconazole is increasingly being used for antifungal prophylaxis during stem cell transplantation. Isavuconazole is a moderate inhibitor of Cytochrome P4503A4, and tacrolimus levels are anticipated to be elevated when given concomitantly with isavuconazole. We… read more here.
Keywords: cell transplantation; stem cell; 017 day; tacrolimus dose ... See more keywords
Effect of Isavuconazonium Sulfate and Posaconazole Delayed Release Tablets on Tacrolimus Dose-to-Concentration Ratios
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DOI: 10.1177/15269248221145036
Abstract: Introduction Limited evidence exists on the effect of isavuconazonium sulfate and posaconazole delayed release tablets on tacrolimus dose-to-concentration ratios in lung transplant recipients. Project Aims The purpose of this evaluation was to assess the impact… read more here.
Keywords: delayed release; dose concentration; posaconazole delayed; release tablets ... See more keywords