Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfy096
Abstract: Background Tacrolimus, a drug for prevention of rejection after kidney transplantation, has a narrow therapeutic window and is metabolized by the cytochrome P540 3A (CYP3A) system. Tacrolimus exposure increases after steroid tapering in many patients.… read more here.
Keywords: steroid tapering; increase; tacrolimus exposure; renal transplant ... See more keywords
Tacrolimus Exposure in Obese Patients: A Case-Control Study in Kidney Transplantation.
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000820
Abstract: BACKGROUND Tacrolimus pharmacokinetics in obese patients have been poorly studied. Herein, the authors explored the impact of obesity on tacrolimus exposure in kidney transplant recipients (KTRs) and estimated a more suitable initial dosage in this… read more here.
Keywords: study; tacrolimus exposure; obese patients; day ... See more keywords
Tacrolimus exposure and intra‐patient variability in paediatric and young adult kidney transplant recipients: one size does not fit all
Sign Up to like & getrecommendations! Published in 2020 at "Transplant International"
DOI: 10.1111/tri.13750
Abstract: Paediatric practice recommendations on the use of tacrolimus following kidney transplantation are largely based on the experience from adult solid organ recipients. It has been reported that adequate tacrolimus exposure in adults can impact patient… read more here.
Keywords: adult; kidney transplant; tacrolimus exposure; tacrolimus ... See more keywords
Increased Tacrolimus Exposure in Kidney Transplant Recipients With COVID-19: Inflammation-Driven Downregulation of Metabolism as a Potential Mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Transplant International"
DOI: 10.3389/ti.2022.10269
Abstract: Kidney transplant recipients (KTRs) are at increased risk of severe COVID-19 disease compared to the general population. This is partly driven by their use of immunosuppressive therapy, which influences inflammatory responses and viral loads. Current… read more here.
Keywords: driven downregulation; inflammation driven; tacrolimus exposure; kidney transplant ... See more keywords