Risk factors and clinical characteristics of tacrolimus-induced acute nephrotoxicity in children with nephrotic syndrome: a retrospective case-control study
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-019-02781-3
Abstract: Purpose Acute nephrotoxicity is a common adverse reaction of tacrolimus therapy; however, its risk factors in pediatric nephrotic syndrome (NS) remain to be evaluated. The objective of this study was to investigate the risk factors… read more here.
Keywords: tacrolimus induced; nephrotoxicity; acute nephrotoxicity; risk factors ... See more keywords
TRPA1 channel participates in tacrolimus-induced pruritus in a chronic contact hypersensitivity murine model.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.10.012
Abstract: Tacrolimus ointment (FK506), a calcineurin inhibitor, is a widely used topical medication in atopic dermatitis (AD) [1]. Although it is effective, pruritus and stinging sensation are common, particularly in AD patients [1]. Mediators of mast… read more here.
Keywords: pruritus; model; tacrolimus induced; hypersensitivity ... See more keywords
The mTOR inhibitor everolimus attenuates tacrolimus-induced renal interstitial fibrosis in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120150
Abstract: AIMS Tacrolimus-a widely used immunosuppressant to prevent allograft rejection after organ transplantation-is nephrotoxic, increasing the risk of kidney injury accompanied by kidney fibrosis. The mammalian target of rapamycin (mTOR) inhibitor, everolimus, is an immunosuppressant used… read more here.
Keywords: everolimus; fibrosis; induced kidney; kidney fibrosis ... See more keywords
The tacrolimus‐induced glucose homeostasis imbalance in terms of the liver: From bench to bedside
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15665
Abstract: Tacrolimus (TAC), the mainstay of maintenance immunosuppressive agents, plays a crucial role in new‐onset diabetes after transplant (NODAT). Previous studies investigating the diabetogenic effects of TAC have focused on the β cells of islets. In… read more here.
Keywords: homeostasis; bench; tac; crtc2 ... See more keywords
Tacrolimus induced dermatophyte infection overlying a plaque morphea
Sign Up to like & getrecommendations! Published in 2017 at "Dermatologic Therapy"
DOI: 10.1111/dth.12395
Abstract: Dear Editor, A 17-year-old man presented with four hyperpigmented indurated plaques, one over the left post-auricular area and three on the anterior aspect of neck since last 1.5 years. The plaques were gradually increasing in… read more here.
Keywords: plaque morphea; morphea; tacrolimus induced; induced dermatophyte ... See more keywords
Analysis of clinical features of tacrolimus‐induced optic neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13658
Abstract: Tacrolimus is associated with optic neuropathy. The clinical features of tacrolimus‐induced optic neuropathy (TION) are unclear. The purpose of this article is to explore the clinical features of TION. read more here.
Keywords: optic neuropathy; features tacrolimus; tacrolimus induced; analysis clinical ... See more keywords
Renal denervation mitigates renal dysfunction in a rat model of tacrolimus-induced nephrotoxicity
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731229
Abstract: Tacrolimus, a macrolide calcineurin inhibitor, is the most widely used immune suppressant medication after solid-organ transplant in humans, however, its use is complicated by nephrotoxicity and the development of chronic kidney disease. Interestingly, transplanted kidneys,… read more here.
Keywords: renal denervation; physiology; tacrolimus induced; tacrolimus ... See more keywords
Delayed tacrolimus-induced optic neuropathy
Sign Up to like & getrecommendations! Published in 2019 at "Neurosciences"
DOI: 10.17712/nsj.2019.4.20190022
Abstract: Tacrolimus is an immunosuppressant agent utilized for solid organ transplantations. It has been associated with rare neurotoxic effects. This case highlights one possible delayed neurotoxic effect. A 52-year-old lady on tacrolimus (3 mg daily) among… read more here.
Keywords: induced optic; tacrolimus induced; optic neuropathy; tacrolimus ... See more keywords
Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress–Activated FOXO1 to Trigger β-Cell Failure
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-0828
Abstract: Active maintenance of β-cell identity through fine-tuned regulation of key transcription factors ensures β-cell function. Tacrolimus, a widely used immunosuppressant, accelerates onset of diabetes after organ transplantation, but underlying molecular mechanisms are unclear. Here we… read more here.
Keywords: metabolic stress; smad signaling; bmp smad; tacrolimus induced ... See more keywords