Tacrolimus-Induced Hyperosmolar Hyperglycemic Syndrome and the Role of Phenytoin in Tacrolimus Toxicity.
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DOI: 10.1097/mjt.0000000000001153
Abstract: To the Editor: Tacrolimus is an immunosuppressant used in organ transplant recipients to decrease the risk of rejection. It is known to cause hyperglycemia through multiple mechanisms. Studies have shown that it induces insulin resistance… read more here.
Keywords: phenytoin tacrolimus; admission; hyperosmolar hyperglycemic; tacrolimus toxicity ... See more keywords
Use of phenytoin for treatment of tacrolimus toxicity with superimposed sepsis
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DOI: 10.1136/bcr-2020-234839
Abstract: A 40-year-old woman with a history of chronic graft-versus-host-disease on immunosuppression with tacrolimus presented to the hospital with somnolence, confusion and muscle cramps over a few days. She was found to have hypertension, hyperglycaemia and… read more here.
Keywords: treatment tacrolimus; tacrolimus toxicity; use phenytoin; tacrolimus ... See more keywords
Phenytoin and Rifampin Do Not Decrease Levels in Acute Tacrolimus Toxicity
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DOI: 10.1177/2324709618765862
Abstract: Tacrolimus is used in bone marrow transplant patients to prevent graft-versus-host disease. There have been few case reports of tacrolimus toxicity (>30 ng/mL) in solid organ recipients as well as in nontransplant patients. Several case… read more here.
Keywords: tacrolimus toxicity; tacrolimus; phenytoin rifampin;