Exposure to tacrolimus trough levels below 6 ng/ml during the first year is associated with inferior kidney graft survival
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Transplantation"
DOI: 10.1111/ctr.14879
Abstract: Accumulating data indicate that sub‐therapeutic levels of tacrolimus are associated with long‐term kidney graft loss. However, elevated doses increase the risk of infection and drug toxicity, which also threaten graft and patient longevity. We sought… read more here.
Keywords: graft survival; exposure tacrolimus; kidney graft; graft ... See more keywords
The Impact of Rivaroxaban and Apixaban on Tacrolimus Trough Levels
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DOI: 10.1177/15269248211024601
Abstract: The solid organ transplant community is slow to adopt the routine practice of using direct oral anticoagulants. Rivaroxaban and apixaban share common metabolic pathways with tacrolimus. This study aimed to clarify the impact of rivaroxaban/apixaban… read more here.
Keywords: tacrolimus troughs; rivaroxaban apixaban; impact rivaroxaban; apixaban ... See more keywords
Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development.
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DOI: 10.1681/asn.2017030287
Abstract: Despite more than two decades of use, the optimal maintenance dose of tacrolimus for kidney transplant recipients is unknown. We hypothesized that HLA class II de novo donor-specific antibody (dnDSA) development correlates with tacrolimus trough… read more here.
Keywords: trough levels; eplet mismatch; development; tacrolimus trough ... See more keywords