Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2016.11.005
Abstract: Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial sciatic nerve (SCN) ligation (PSL) in mice. IL-13 receptor α1… read more here.
Keywords: reverses inflammatory; inflammatory macrophage; tactile allodynia; partial sciatic ... See more keywords
Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.07.029
Abstract: Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics… read more here.
Keywords: strength; grip strength; rheumatology; tactile allodynia ... See more keywords
Brain activity for tactile allodynia: a longitudinal awake rat functional magnetic resonance imaging study tracking emergence of neuropathic pain
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DOI: 10.1097/j.pain.0000000000000788
Abstract: Abstract Tactile allodynia, a condition in which innocuous mechanical stimuli are perceived as painful, is a common feature of chronic pain. However, how the brain reorganizes in relation to the emergence of tactile allodynia is… read more here.
Keywords: imaging; brain; tactile allodynia; functional magnetic ... See more keywords
Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug–unresponsive hyperalgesia in male rats
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DOI: 10.1097/j.pain.0000000000001373
Abstract: Abstract Although nonsteroidal anti-inflammatory drugs are the first line of therapeutics for the treatment of mild to moderate somatic pain, they are not generally considered to be effective for neuropathic pain. In the current study,… read more here.
Keywords: anti inflammatory; drug unresponsive; nonsteroidal anti; inflammatory drug ... See more keywords
Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.820664
Abstract: Our previous studies have clarified that red nucleus (RN) interleukin (IL)-6 is involved in the maintenance of neuropathic pain and produces a facilitatory effect by activating JAK2/STAT3 and ERK pathways. In this study, we further… read more here.
Keywords: red nucleus; inflammatory cytokines; anti inflammatory; pro inflammatory ... See more keywords