Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03017-1
Abstract: The metazoan genome is compartmentalized in areas of highly interacting chromatin known as topologically associating domains (TADs). TADs are demarcated by boundaries mostly conserved across cell types and even across species. However, a genome-wide characterization… read more here.
Keywords: stratification tad; tad; strong boundaries; insulation ... See more keywords
A comparison of topologically associating domain callers based on Hi-C data.
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2022.3147805
Abstract: Topologically associating domains (TADs) are local chromatin interaction domains, which have been shown to play an important role in gene expression regulation. TADs were originally discovered in the investigation of 3D genome organization based on… read more here.
Keywords: comparison topologically; associating domain; callers based; tad boundaries ... See more keywords