Can changes in 3D genome architecture create new regulatory landscapes that contribute to phenotypic evolution?
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DOI: 10.1042/ebc20220057
Abstract: Animal genomes are compartmentalized into insulated regulatory units named topology-associated domains (TADs). TADs insulate gene promoters from enhancers that occupy neighboring TADs. Chromosomal rearrangements that disrupt TAD structure can generate new regulatory interactions between enhancers… read more here.
Keywords: tad structure; evolution; changes genome; gene ... See more keywords