Cyclic guanosine monophosphate modulates accumulation of phosphodiesterase 5 inhibitors in human platelets
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.08.026
Abstract: ABSTRACT Sildenafil and tadalafil are widely‐used phosphodiesterase 5 (PDE5) inhibitors for which no clear dose‐response relationship could be established. Using isolated and/or recombinant PDE5, it has been demonstrated that cGMP can increase the affinity of… read more here.
Keywords: guanosine monophosphate; sildenafil tadalafil; tadalafil; pde5 ... See more keywords
The Daily Therapy With L-Arginine 2,500 mg and Tadalafil 5 mg in Combination and in Monotherapy for the Treatment of Erectile Dysfunction: A Prospective, Randomized Multicentre Study
Sign Up to like & getrecommendations! Published in 2020 at "Sexual Medicine"
DOI: 10.1016/j.esxm.2020.02.003
Abstract: Introduction A synergistic effect of the combination therapy tadalafil plus L-Arginine is conceivable in patients affected by erectile dysfunction (ED). Aim To evaluate the effectiveness and tolerability of tadalafil 5 mg and L-Arginine 2.5 grams… read more here.
Keywords: combination; tadalafil; treatment; group ... See more keywords
Maternal administration of tadalafil improves fetal ventricular systolic function in a Hey2 knockout mouse model of fetal heart failure.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.12.013
Abstract: BACKGROUND There is no established transplacental treatment for heart failure (HF) in utero, and no animal models or experimental systems of fetal HF have been established. This study aimed to investigate the effect of maternal… read more here.
Keywords: tadalafil; model fetal; systolic function; hey2 embryos ... See more keywords
Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation-predominant irritable bowel syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117960
Abstract: BACKGROUND Intestinal GC-C/cGMP pathway may be involved in visceral hypersensitivity and fluid secretion in irritable bowel syndrome (IBS). The guanylcyclase C agonist linaclotide, approved for IBS- constipation, is contraindicated in children as it may cause… read more here.
Keywords: ibs; irritable bowel; tadalafil; tadalafil linaclotide ... See more keywords
Comparison of Silodosin Monotherapy vs Silodosin With Tadalafil Add-on Therapy in Patients With Benign Prostatic Hyperplasia.
Sign Up to like & getrecommendations! Published in 2017 at "Urology"
DOI: 10.1016/j.urology.2017.04.012
Abstract: OBJECTIVE To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil for patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH) treated with the α1-adrenoceptor blocker… read more here.
Keywords: add therapy; benign prostatic; tadalafil; silodosin ... See more keywords
Re: Adding a Vacuum Erection Device to Regular Use of Tadalafil Improves Penile Rehabilitation after Posterior Urethroplasty.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Urology"
DOI: 10.1097/01.ju.0000578880.72414.a6
Abstract: available at http://www.ncbi.nlm.nih.gov/pubmed/31169141 Editorial Comment: This study evaluated whether adding a vacuum erection device (VED) to regular use of tadalafil could achieve better penile rehabilitation following posterior urethroplasty for pelvic fracture related urethral injury. Altogether… read more here.
Keywords: posterior urethroplasty; erection; tadalafil; regular use ... See more keywords
Improved molecular softness of tadalafil hapten enhancing antibody performance in immunoassay: Evidence from computational chemistry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food science"
DOI: 10.1111/1750-3841.16078
Abstract: The tadalafil-like compounds have appeared recently as adulterants in drinks and healthcare dietary supplements sourced from medicinal and edible food, which may cause illness and even death. In this work, the rationality of haptens was… read more here.
Keywords: computational chemistry; like adulterants; tadalafil like; food ... See more keywords
Comparison of three different tadalafil regimens for erectile dysfunction treatment in patients with diabetes mellitus microvascular complications
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DOI: 10.1111/and.14536
Abstract: We aimed to compare the efficacy of three tadalafil regimens for patients with type‐2 diabetes mellitus (DM), at least one microvascular complication and erectile dysfunction (ED). Sixty patients attending our urology clinic with erectile problems… read more here.
Keywords: tadalafil regimens; erectile dysfunction; group; diabetes mellitus ... See more keywords
Bioequivalence of macitentan and tadalafil given as fixed‐dose combination or single‐component tablets in healthy subjects
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14347
Abstract: To demonstrate the bioequivalence of macitentan/tadalafil fixed‐dose combination (FDC) tablets with single‐component tablets of macitentan and tadalafil in healthy subjects. read more here.
Keywords: dose combination; tadalafil; macitentan tadalafil; single component ... See more keywords
Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency?
Sign Up to like & getrecommendations! Published in 2021 at "Urologia Internationalis"
DOI: 10.1159/000514056
Abstract: Introduction: Numerous factors such as endothelial disease and hormonal disorder cause the development of erectile dysfunction (ED). However, the relationship between vitamin D deficiency (VDD) and ED is unclear. Moreover, the benefit of vitamin D… read more here.
Keywords: patients vdd; tadalafil; treatment; adding vitamin ... See more keywords
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Tamsulosin Plus Tadalafil Compared With Tamsulosin Alone in Treating Males With Lower Urinary Tract Symptoms Secondary to Benign Prostrate Hyperplasia
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Men's Health"
DOI: 10.1177/15579883231155096
Abstract: Lower urinary tract symptoms (LUTS) secondary to benign prostrate hyperplasia (BPH) are common geriatric diseases, and its incidence rises with age. The treatment of BPH and LUTS is becoming a burden for health care. The… read more here.
Keywords: safety; tamsulosin alone; lower urinary; tamsulosin ... See more keywords