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   Articles with "tadalafil" as a keyword



The association of tadalafil exposure with lower rates of major adverse cardiovascular events and mortality in a general population of men with erectile dysfunction

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recommendations! Published in 2024 at "Clinical Cardiology"

DOI: 10.1002/clc.24234

Abstract: Tadalafil is a long‐acting phosphodiesterase‐5 inhibitor (PDE‐5i) indicated for erectile dysfunction (ED). read more here.

Keywords: tadalafil; association tadalafil; exposure lower; tadalafil exposure ... See more keywords

A Systematic Literature Review Exploring the Efficacy and Safety of Tadalafil and Sildenafil in Pulmonary Arterial Hypertension

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recommendations! Published in 2025 at "Pulmonary Circulation"

DOI: 10.1002/pul2.70212

Abstract: ABSTRACT Pulmonary Arterial Hypertension (PAH) is a rare, chronic and progressive disease affecting the heart and lungs. Endothelin receptor antagonist (ERA) + phosphodiesterase type 5 inhibitor (PDE5i) treatment is recommended for all PAH patients. The… read more here.

Keywords: tadalafil; tadalafil sildenafil; arterial hypertension; pulmonary arterial ... See more keywords

Single-dose Tadalafil Reduces Opening Urethral Pressure: A Randomized, Double-blind, Placebo-controlled, Crossover Trial in Healthy Women

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recommendations! Published in 2024 at "International Urogynecology Journal"

DOI: 10.1007/s00192-024-05757-9

Abstract: Phosphodiesterase enzymes are widely distributed in female urogenital tissues. Yet, the understanding of their physiological roles and the impact of phosphodiesterase inhibitors on lower urinary tract symptoms in women remains limited. Current hypotheses are conflicting:… read more here.

Keywords: pressure; tadalafil; single dose; urethral pressure ... See more keywords

Cyclic guanosine monophosphate modulates accumulation of phosphodiesterase 5 inhibitors in human platelets

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recommendations! Published in 2017 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2017.08.026

Abstract: ABSTRACT Sildenafil and tadalafil are widely‐used phosphodiesterase 5 (PDE5) inhibitors for which no clear dose‐response relationship could be established. Using isolated and/or recombinant PDE5, it has been demonstrated that cGMP can increase the affinity of… read more here.

Keywords: guanosine monophosphate; sildenafil tadalafil; tadalafil; pde5 ... See more keywords
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The Daily Therapy With L-Arginine 2,500 mg and Tadalafil 5 mg in Combination and in Monotherapy for the Treatment of Erectile Dysfunction: A Prospective, Randomized Multicentre Study

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recommendations! Published in 2020 at "Sexual Medicine"

DOI: 10.1016/j.esxm.2020.02.003

Abstract: Introduction A synergistic effect of the combination therapy tadalafil plus L-Arginine is conceivable in patients affected by erectile dysfunction (ED). Aim To evaluate the effectiveness and tolerability of tadalafil 5 mg and L-Arginine 2.5 grams… read more here.

Keywords: combination; tadalafil; treatment; group ... See more keywords

Maternal administration of tadalafil improves fetal ventricular systolic function in a Hey2 knockout mouse model of fetal heart failure.

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recommendations! Published in 2019 at "International journal of cardiology"

DOI: 10.1016/j.ijcard.2019.12.013

Abstract: BACKGROUND There is no established transplacental treatment for heart failure (HF) in utero, and no animal models or experimental systems of fetal HF have been established. This study aimed to investigate the effect of maternal… read more here.

Keywords: tadalafil; model fetal; systolic function; hey2 embryos ... See more keywords

Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation-predominant irritable bowel syndrome.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.117960

Abstract: BACKGROUND Intestinal GC-C/cGMP pathway may be involved in visceral hypersensitivity and fluid secretion in irritable bowel syndrome (IBS). The guanylcyclase C agonist linaclotide, approved for IBS- constipation, is contraindicated in children as it may cause… read more here.

Keywords: ibs; irritable bowel; tadalafil; tadalafil linaclotide ... See more keywords

Comparison of Silodosin Monotherapy vs Silodosin With Tadalafil Add-on Therapy in Patients With Benign Prostatic Hyperplasia.

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recommendations! Published in 2017 at "Urology"

DOI: 10.1016/j.urology.2017.04.012

Abstract: OBJECTIVE To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil for patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH) treated with the α1-adrenoceptor blocker… read more here.

Keywords: add therapy; benign prostatic; tadalafil; silodosin ... See more keywords

Potential of tadalafil and tadalafil-cellulose nanocomposite in preventing postsurgical abdominal adhesions in a rat cecal abrasion model

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-14894-0

Abstract: The formation of postoperative intra-abdominal adhesions is a significant challenge in veterinary practice worldwide. Thus, several attempts have been made to identify agents that prevent the occurrence of these postsurgical adhesions. However, finding an ideal… read more here.

Keywords: tadalafil; intra abdominal; tadalafil cellulose; abdominal adhesions ... See more keywords

Re: Adding a Vacuum Erection Device to Regular Use of Tadalafil Improves Penile Rehabilitation after Posterior Urethroplasty.

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recommendations! Published in 2019 at "Journal of Urology"

DOI: 10.1097/01.ju.0000578880.72414.a6

Abstract: available at http://www.ncbi.nlm.nih.gov/pubmed/31169141 Editorial Comment: This study evaluated whether adding a vacuum erection device (VED) to regular use of tadalafil could achieve better penile rehabilitation following posterior urethroplasty for pelvic fracture related urethral injury. Altogether… read more here.

Keywords: posterior urethroplasty; erection; tadalafil; regular use ... See more keywords

Improved molecular softness of tadalafil hapten enhancing antibody performance in immunoassay: Evidence from computational chemistry.

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recommendations! Published in 2022 at "Journal of food science"

DOI: 10.1111/1750-3841.16078

Abstract: The tadalafil-like compounds have appeared recently as adulterants in drinks and healthcare dietary supplements sourced from medicinal and edible food, which may cause illness and even death. In this work, the rationality of haptens was… read more here.

Keywords: computational chemistry; like adulterants; tadalafil like; food ... See more keywords